The Role of Oxygen Radicals in Cardiovascular Diseases

A Conference in the European Concerted Action on Breakdown in Human Adaptation — Cardiovascular Diseases, held in Asolo, Italy, 2–5 December 1986

  • A. L’Abbate
  • F. Ursini

Table of contents

  1. Front Matter
    Pages i-x
  2. Gian Paolo Novelli
    Pages 13-22
  3. A. Bindoli, L. Cavallini, M. P. Rigobello, M. Coassin, F. Di Lisa
    Pages 51-69
  4. Fulvio Ursini, Gualtiero Pelosi, Antonio Benassi, Renata Barsacchi
    Pages 91-104
  5. Diego Mira, Ulf Brunk, Fulvio Ursini, Enrique Cadenas
    Pages 105-116
  6. J. F. Koster, H. Stam, P. Biemond
    Pages 117-125
  7. D. O. Levitsky, A. V. Lebedev, A. V. Kuzmin, V. M. Brovkovich
    Pages 127-141
  8. Bruce A. Freeman, Peter Panus, Joseph S. Beckman, Sadis Matalon
    Pages 201-215

About this book


Growing experimental evidence is beeing produced in support of the thesis that lipid pe,oxidation is an important mediator of both vascular and myocardial tissue derangement. Although the role of the free-radical system in human cardiovascular pathology remains speculative, nevertheless the potential implications of such a system in both pharmacological therapy and prevention of major cardiovascular diseases, such as myocardial infarction, cardiomyopathy and arrhythmias, justify the increasing interest of clinical cardiologists in this research area. Furthermore, present-day clinical cardiology permits to reproduce in man such experimental models as ischemia and reperfusion, e.g. during percutaneous transluminal angioplasty, and even to gain histological and histochemical access to byoptic myocardial tissue. Upon above premises the idea of a multidisciplinary discussion meeting was conceived, aimed to confront clinical expectations with acquired basic information, and to discuss the validity of experimental models in the light of pathological and clinical findings in man. To this purpose, a unique group of experts in the field of free-radicals, from all over the world, was asked to make the topic accessible to clinical cardiologists, with the primary aim of projecting results and ideas towards potential clinical research; this is, in fact, the object of the European Concerted Action "Breakdown in Human Adaptation - Cardiovascular Diseases", in the frame of which the meeting was held.


arrhythmia atherosclerosis cardiology cardiovascular heart heart disease myocardial infarction platelet vascular disease

Editors and affiliations

  • A. L’Abbate
    • 1
  • F. Ursini
    • 2
  1. 1.Institute of Clinical PhysiologyCNRPisaItaly
  2. 2.Institute of BiochemistryPadovaItaly

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1988
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7716-3
  • Online ISBN 978-94-009-2697-4
  • Buy this book on publisher's site