Triggering of Acute Coronary Syndromes

Implications for Prevention

  • Stefan N. Willich
  • James E. Muller

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 170)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Epidemiology

  3. Physiology

    1. François Cambien, Odette Poirier, Alun Evans, Dominique Arveiler, Gérald Luc, Jean-Pierre Cambou et al.
      Pages 111-133
    2. Praveen P. Jadhav, Geoffrey H. Tofler
      Pages 135-151
    3. Kaj Winther, Steen Elkjær Husted, Hans Kræmmer Nielsen, Jørn Dalsgaard Nielsen
      Pages 153-173
    4. Felicita Andreotti, Alessandro Manzoli
      Pages 185-199
    5. Antonio Fernández-Ortiz, Valentín Fuster
      Pages 201-218
  4. Pathology

  5. Prevention

  6. Back Matter
    Pages 413-428

About this book


Cardiovascular diseases account for about half of total mortality in industrialised societies. This figure has declined only slightly and in few countries over the past few decades, which is disturbing in view of our increasing insight into long-term risk factors of coronary heart disease and the dramatic improvement in the acute therapy of its manifestations. One important reason for this is the high fatality during the initial hours of a coronary event, i.e. before medical treatment can be provided. Approximately one quarter of all patients suffering an acute cardiac event die prior to admission to hospital.
As a result, the focus of current research has shifted from after-the-fact therapy to the triggering phase of acute coronary disease. Epidemiological observations of recent trends and newly identified determinants of coronary disease and the results of substantial pathophysiological studies of the conversion from chronic coronary disease to an acute event provide the basis for new hypotheses about the triggering mechanisms. The ultimate goal is to design more effective preventive strategies for these deadly diseases.
The present extensive summary of important scientific and clinical developments in the study of the triggering and prevention of coronary syndromes that have been seen over the last ten years contains the contributions of leading experts in the field. It presents a cooperative, balanced view derived from physicians and researchers in the U.S. and Europe.


cardiovascular coronary artery disease electrophysiology gene therapy heart sudden cardiac death vascular disease

Editors and affiliations

  • Stefan N. Willich
    • 1
  • James E. Muller
    • 2
  1. 1.Institute for Epidemiology, Social and Preventive MedicineHumboldt University of Berlin, Klinikum CharitéBerlinGermany
  2. 2.Institute for Prevention of Cardiovascular Disease, Deaconess HospitalHarvard Medical SchoolBostonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1996
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7205-2
  • Online ISBN 978-94-009-1577-0
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site