Immunopathogenetic Mechanisms of Arthritis

  • J. A. Goodacre
  • W. Carson Dick

Table of contents

  1. Front Matter
    Pages i-ix
  2. O. T. G. Jones, A. R. Cross
    Pages 1-25
  3. R. R. P. De Vries
    Pages 51-68
  4. A. M. Solinger
    Pages 86-100
  5. F. S. Di Giovine, J. A. Symons, J. Manson, G. W. Duff
    Pages 101-121
  6. L. Klareskog, H. Wigzell
    Pages 143-156
  7. C. J. M. Melief
    Pages 174-183
  8. B. Pal, I. D. Griffiths
    Pages 184-197
  9. D. Alarcón-Segovia
    Pages 198-210
  10. Back Matter
    Pages 247-252

About this book


The fundamental problem facing scientists and clinicians in Rheumatology is that so little is known about the biology of joints. It is our view that a real interface between basic and clinical science offers the best chance of gaining a better understanding of arthritis and in this book we aim to provide a basis for such an interface. Each chapter provides a lucid account of the current literature, reflecting the eminence of each author in their own field. The contributors offer a variety of modern approaches to the study of inflammatory joint disease, illustrating some of the exciting opportunities for research which exist. We hope that those who share our view find these pages informative and stimulating. University of Newcastle upon Tyne, 1987. JOHN A. GOODACRE W. CARSON DICK ix 1 • Polymorphonuclear leukocytes In acute inflammation O. T. G. JONES and A. R. CROSS INTRODUCTION The nonnal function of the professional phagocytes - polymorphonuclear leukocytes (PMN), monocytes, macrophages and eosinophils - is to protect the individual from microbial infection by seeking out and destroying the invading microbes. In order to perform this function effectively the phagocyte must move towards sites of infection, recognize, phagocytose, kill and digest the microbe and, if necessary, recruit other cells to assist. These phagocytic cells possess a membrane-bound enzyme system which can be activated to produce toxic oxygen radicals in response to a wide variety of stimuli.


genetics immunity infection inflammation macrophages pathogenesis pathology

Editors and affiliations

  • J. A. Goodacre
    • 1
  • W. Carson Dick
    • 1
  1. 1.Department of RheumatologyRoyal Victoria InfirmaryNewcastle upon TyneUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1988
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7075-1
  • Online ISBN 978-94-009-1293-9
  • Buy this book on publisher's site