Bile Acids in Health and Disease

Update on Cholesterol Gallstones and Bile Acid Diarrhoea

  • Tim Northfield
  • Riadh Jazrawi
  • Patrick Zentler-Munro

Table of contents

  1. Front Matter
    Pages i-x
  2. Overview

  3. Biliary Chemistry and Physiology

    1. Front Matter
      Pages 19-19
    2. J. M. Graham, H. Ahmed, T. C. Northfield
      Pages 27-41
    3. R. Coleman, K. L. Rahman, M. E. Bellringer, M. Carrella
      Pages 43-60
    4. M. C. Carey
      Pages 61-82
    5. A. Lanzini, T. C. Northfield
      Pages 83-96
  4. Pathogenesis of Cholesterol Gallstone Disease

    1. Front Matter
      Pages 97-97
    2. K. Einarsson, B. Angelin
      Pages 99-116
    3. R. T. Holzbach, R. L. Barnhart, J. M. Nader
      Pages 117-133
    4. I. C. Forgacs
      Pages 135-153
  5. Gallstone Prevention

    1. Front Matter
      Pages 155-155
    2. K. W. Heaton
      Pages 157-169
    3. K. A. Hood
      Pages 171-180
  6. Non-Surgical Treatment of Gallstones

    1. Front Matter
      Pages 181-181
    2. L. Barbara, F. Bazzoli, E. Roda
      Pages 183-186
    3. M. Podda, M. Zuin, P. M. Battezzati
      Pages 187-194
    4. J. L. Thistle
      Pages 195-200
    5. G. Paumgartner, M. Sackmann, J. Holl, T. Sauerbruch
      Pages 201-204
    6. T. C. Northfield, R. P. Jazrawi
      Pages 205-213
  7. Lipid Digestion and Bile Acid Absorption

    1. Front Matter
      Pages 215-215
    2. B. Borgström
      Pages 217-228
    3. A. Stiehl
      Pages 229-235
  8. Lipid Maldigestion and Bile Acid Malabsorption

    1. Front Matter
      Pages 237-237
    2. P. L. Zentler-Munro, D. R. Fine, T. C. Northfield
      Pages 239-251
    3. M. Eastwood, M. Merrick
      Pages 267-273
  9. Diagnosis of Bile Acid Malabsorption — Role of 75SeHCAT

    1. Front Matter
      Pages 275-275
    2. R. P. Jazrawi, R. Ferraris, T. C. Northfield
      Pages 277-289
    3. G. Sciarretta, G. Fagioli, A. Furno, G. Vicini, P. Malaguti
      Pages 291-299
    4. R. Ferraris
      Pages 301-306
  10. Back Matter
    Pages 307-314

About this book


Bile acids occupy a central position in in the absorption, excretion and metab­ olism of lipids within the body. Our understanding of their unique properties has illuminated many biochemical and biophysical processes. Animals have evolved a unique system of preserving these important detergent-like molecules within the body and reusing them many times - the enterohepatic circulation. Disorders of the enterohepatic circulation contribute to a correspondingly wide range of diseases, and recent developments have centred in particular on cholesterol gallstone disease and bile acid diarrhoea. Successful manage­ ment of these diseases is increasingly based on an understanding of the physicochemical and biochemical properties of bile acids, and of their pathophysiological role in disease. Professor Alan Hofmann starts this book with an overview of the enterohepatic circulation of bile acids. The first section then discusses biliary lipid synthesis, transport and secretion by the liver and the solubilisation of cholesterol in the bile. The next section applies this knowledge to the pathogenesis of cholesterol gallstones. Separate chapters focus on defects in biliary lipid secretion, in cholesterol solubilisation and in gallbladder motility. The succeeding sections then review posssible approaches to gallstone prevention, and assess recent developments in non-surgical forms oftreatment. Two exciting new therapies that receive particular attention are contact dissolution therapy with methyl tert-butyl ether and extracorporeal shock wave lithotripsy. Further sections turn to the absorptive functions of bile acids in health.


absorption attention bile bile acid diagnosis diseases enterohepatic circulation epidemiology gallbladder gallstone health irritable bowel syndrome liver molecule physiology

Editors and affiliations

  • Tim Northfield
    • 1
  • Riadh Jazrawi
    • 1
  • Patrick Zentler-Munro
    • 1
  1. 1.Department of MedicineSt. George’s Hospital Medical SchoolLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1988
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7054-6
  • Online ISBN 978-94-009-1249-6
  • Buy this book on publisher's site