Recent Developments in Prophylactic Immunization

  • A. J. Zuckerman

Part of the Immunology and Medicine book series (IMME, volume 12)

Table of contents

  1. Front Matter
    Pages i-x
  2. L. A. E. Ashworth, A. Robinson
    Pages 1-19
  3. R. A. Wall
    Pages 20-46
  4. H. M. Dockrell, K. P. W. J. McAdam
    Pages 62-73
  5. J. E. Pennington
    Pages 74-85
  6. R. B. Heath
    Pages 86-96
  7. K. G. Nicholson
    Pages 114-154
  8. J. E. Banatvala, J. M. Best
    Pages 155-180
  9. R. W. Ellis, P. J. Provost
    Pages 181-209
  10. A. R. Neurath
    Pages 210-242
  11. A. J. Morgan, M. A. Epstein
    Pages 243-254
  12. P. J. Greenaway
    Pages 255-288
  13. G. L. Smith
    Pages 313-333
  14. Back Matter
    Pages 334-340

About this book


It has been said that "never in the history of human progress has a better and cheaper method of preventing illness been developed than immunization". This is well illustrated by the WHO Expanded Programme on Immunization (EPI) which in developing countries is now preventing nearly a million deaths annually from measles, pertussis and neonatal tetanus, and for which there is a commitment by the WHO and UNICEF to protect all children by immunization by the end of the decade. This enormous undertaking will be facilitated by the rapid advances in molecular biology and recombinant DNA technology, in the understanding of immunological mechanisms and by the production and application of monoclonal antibodies so that the structure and location of important antigenic determinants or epitopes can be determined. Chemical synthesis of oligopeptides has been simplified, and computer programmes and X-ray crystallography provide the tools for the determination of three-dimensional structure of proteins, so that the structure and location of important antigenic determinants or epitopes can be predicted. These techniques have opened the way to the improvement of existing vaccines and to the development and production of new vaccines against infections for which vaccines are not available. New vaccines under development include vaccines against hepatitis B, hepatitis A, malaria, vaccines for typhoid, cholera, rota virus infection and other diarrhoeal diseases, leprosy, rabies, the acquired immune deficiency syndrome (AIDS), rubella, EB virus, schistosomiasis and other infections. These recent developments are discussed in the volume by internationally recognized experts assembled from several countries.


AIDS bacteria infection molecular biology pseudomonas vaccine virus

Editors and affiliations

  • A. J. Zuckerman
    • 1
  1. 1.Department of Medical Microbiology, London School of Hygiene and Tropical MedicineUniversity of LondonLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1989
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6969-4
  • Online ISBN 978-94-009-1067-6
  • Buy this book on publisher's site