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Clinical Application of Radiolabelled Platelets

  • Ch. Kessler
  • M. R. Hardeman
  • H. Henningsen
  • J.-N. Petrovici
Book

Part of the Developments in Nuclear Medicine book series (DNUM, volume 17)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Platelet Labelling Techniques

    1. J. P. Lavender, A. M. Peters, A. W. J. Stuttle, S. G. Needham, I. Loutfi, D. Snook et al.
      Pages 26-27
    2. D. A. J. Galvin, A. C. Meek, R. A. Harper, C. N. McCollum
      Pages 28-32
    3. W. Becker, U. Borst, M. Weppler, E. P. Kromer, W. Burner
      Pages 33-44
    4. H. Louwes, J. J. Schuur
      Pages 45-60
  3. Radiolabelled Platelets in Cardiology

  4. Monitoring of Antiplatelet Therapy

  5. Platelet Scintigraphy in Stroke Patients

    1. M. Goldman
      Pages 173-179
    2. E. B. Ringelstein, A. Wicke, M. Holken, G. Fiedler, C. Weiller, U. Bull
      Pages 180-194
    3. A. C. Meek, D. A. J. Galvin, R. A. Harper, C. H. McCollum
      Pages 195-203
    4. A. C. Meek, A. D. Chidlow, P. M. Jarvis, C. N. McCollum
      Pages 204-209
    5. M. Brenner, R. Berberich, A. Haass, G. Huber, H. Jäger
      Pages 210-213
  6. Platelet Scintigraphy in Angiology

    1. J. Bannenberg, K. Breuker, M. R. Hardeman, J. Feijen, P. J. Klopper
      Pages 235-241
    2. A. C. Meek, D. A. J. Galvin, R. A. Harper, C. N. McCollum
      Pages 242-247
  7. Hematology and Other Clinical Applications

    1. Ruth A. Harper, W. Th. Goedemans, Alan C. Meek, Charles N. McCollum
      Pages 258-263
    2. Gary V. Desir, Margaret Bia, Robert C. Lange, Eileen O. Smith, Wayne Flye, Michael Kashgarian et al.
      Pages 264-277
    3. C. Piera, M. Roca, J. Martin-Comin, F. Lomena, J. Mora, L. Sanchez et al.
      Pages 278-292
  8. Back Matter
    Pages 293-295

About this book

Introduction

AIMS OF THE COLOGNE-SYMPOSIUM ON RADIOLABELLED PLATELETS In 1976, M. Thakur et al (1) were the first to publish a paper concerning the in vivo thrombus detection with 111- In-labelled platelets. Previous attempts at scintigraphic thrombus localisation had been disappointing because of the unspecific binding of a number of the isotopes used, as well as the poor labelling efficiency or an insufficient low gamma-emitting property. Because of its physical characteristics (2.8 days half-life, 94% gamma emission) 111 Indium turned out to be the best isotope for platelet kinetic studies as well as for the measurement of platelet incorporation by Thrombi to be used up until now. The lipophile complexes of Ill-In (8-hydroxyquinoline, acetylacetone, tropolone) diffuse passively into the platelets without altering the function or the life span of the platelets. This advantage has let to an increase in the clinical applications of 1211-In labelled platelets. Today, radiolabelled platelets are used for thrombus detection in several different medical areas such as cardiology, nephrology. angiology or neurology. Even though many scientists and hospital doctors now routinely use radiolabelled platelet as a diagnostic tool, there is as yet not a standardized labelling method. In addition to this, there are neither standardized image procedures for the different clinical applications nor an agreement about specificity and sensitivity of the method. In 1983, a symposium on Radiolabelled Cellular Blood Elements was organized by M.Thakur, M.R.Hardeman and M.D.

Keywords

Scintigraphy cardiology cardiovascular diagnosis embolism imaging sepsis stroke thrombosis transplantation vascular disease

Editors and affiliations

  • Ch. Kessler
    • 1
  • M. R. Hardeman
    • 2
  • H. Henningsen
    • 3
  • J.-N. Petrovici
    • 4
  1. 1.Department of NeurologyMedical University LübeckLübeckGermany
  2. 2.Department of Internal Medicine, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands
  3. 3.Department of NeurologyUniversity of HeidelbergHeidelbergGermany
  4. 4.Department of NeurologyCologne-Merheim HospitalCologneGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-0581-8
  • Copyright Information Springer Science+Business Media B.V. 1990
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6749-2
  • Online ISBN 978-94-009-0581-8
  • Buy this book on publisher's site