PTCA An Investigational Tool and a Non-Operative Treatment of Acute Ischemia

  • Patrick W. Serruys
  • Rüdiger Simon
  • Kevin J. Beatt

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 101)

Table of contents

  1. Front Matter
    Pages i-xix
  2. An investigational tool

    1. Front Matter
      Pages 1-1
    2. From in-vitro to in-vivo model

      1. Guy R. Heyndrickx, Williamas Wijns, Stephen F. Vatner
        Pages 3-22
      2. Patrick W. Serruys, Brian Jaski, Federico Piscione, Folkert Ten Kate, Pim De Feyter, Marcel Van Den Brand et al.
        Pages 23-35
    3. Role of collaterals during PTCA

      1. B. De Bruyne, B. Meier
        Pages 75-91
    4. Coronary flow and flow reserve

      1. Patrick W. Serruys, Felix Zijlstra, Hans H. C. Reiber, Kevin Beatt, G. J. Laarman, Jos Roelandt et al.
        Pages 93-120
    5. Myocardial metabolism

      1. Patrick W. Serruys, Federico Piscione, William Wijns, Johan A. J. Hegge, Eef Harmsen, Marcel Van Den Brand et al.
        Pages 127-142
      2. Jan Willem De Jong, Tom Huizer, J. Arly Nelson, Wlodzimierz Czarnecki, Johannes J. R. M. Bonnier, Patrick W. Serruys
        Pages 143-150
      3. Harald Tillmanns, Rainer Zimmermann, Wolfram H. Knapp, Frantisek Helus, Peter Georgi, Bernhard Rauch et al.
        Pages 151-154
    6. Myocardial function

      1. M. Grbic, U. Sigwart
        Pages 167-174
      2. Michel E. Bertrand, Jean M. Lablanche, Jean L. Fourrier, Antoine Gommeaux, Israel Mirsky
        Pages 175-191
      3. Michael S. Norell, Raphael Balcon
        Pages 193-205
      4. Cees A. Visser, Jacques J. Koolen, George K. David, Arend J. Dunning
        Pages 207-216
      5. Anthony C. Pearson, Arthur J. Labovitz, Morton Kern, Michel Vandormael
        Pages 217-231
      6. Patrick W. Serruys, Federico Piscione, William Wijns, Cees Slager, Pim De Feyter, Marcel Van Den Brand et al.
        Pages 233-266
    7. Therapeutic effects

      1. Andrew Zalewski, Michael Savage, Sheldon Goldberg
        Pages 267-282
      2. Rüdiger Simon, Gunhild Herrmann, Ivo Amende, Gert H. Reil, Paul R. Lichtlen
        Pages 305-317
  3. Non-operative treatment of acute ischemic

    1. Front Matter
      Pages 333-333
    2. P. J. De Feyter, H. Suryapranata, P. W. Serruys
      Pages 335-356
    3. Harry Suryapranata, Pim J. De Feyter, Patric W. Serruys
      Pages 357-372
    4. M. L. Simoons, P. J. De Feyter, H. Suryapranata
      Pages 373-383
  4. Back Matter
    Pages 405-410

About this book


Obstruction of coronary blood flow and the resultant consequences are the center stage pathophysiologic events in cardiology today. The speculations of Jenner, Burns, Heberdin, McKenzie, Prinzmetal and many others had until now been left to observations of isolated tissue and intact animal experimentation. Only with the advent of Gruentzig's technique, which allowed us to 'work safely inside the coronary arteries' are we able to observe the effects of coronary occlusion in living conscious man. PTCA provides not only a therapeutic modality for non-operatively opening coronary obstructions, but has also provided the best model for studying the effects of acute ischemia on the heart. The procedure also lead the way to all other interventional cardiology developments, including modern thrombolysis in the setting of acute myocardial infarction. In his previous works, Serruys has examined how PTCA can serve as a model for studying acute ischemia. In this book, he and his co-authors discuss the effects of balloon-induced ischemia on the electrocardiographic changes, coronary blood flow dynamics, cardiac muscle metabolism and left ventricular function, as well as measures to counter these effects and provide for reperfusion in unstable angina and acute myocardial infarction. Technology has expanded the 'eyes' of the observer of these events. The authors use many techniques including ECG recording from surface, endocardium, and intracoronary electrodes; angiographic assessment of coronary flow pattern using digital techniques, as well as doppler flow measurements; biochemical assessment of metabolic products stimulated by ischemia; and digital angiographic and echo doppler assessment of left ventricular function.



Editors and affiliations

  • Patrick W. Serruys
    • 1
  • Rüdiger Simon
    • 2
  • Kevin J. Beatt
    • 3
  1. 1.Cardiac Catheterization Laboratory, Thorax CenterErasmus UniversityRotterdamThe Netherlands
  2. 2.Department of CardiologyUniversity HospitalKielGermany
  3. 3.Academic Unit of Cardiovascular MedicineCharing Cross and Westminster HospitalLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1990
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6688-4
  • Online ISBN 978-94-009-0453-8
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site