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Vasopressin

Disturbed Secretion and Its Effects

  • L. Kovács
  • B. Lichardus

Part of the Developments in Nephrology book series (DINE, volume 25)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. L. Kovács, B. Lichardus
    Pages 1-12
  3. L. Kovács, B. Lichardus
    Pages 13-18
  4. L. Kovács, B. Lichardus
    Pages 19-29
  5. L. Kovács, B. Lichardus
    Pages 30-37
  6. L. Kovács, B. Lichardus
    Pages 38-62
  7. L. Kovács, B. Lichardus
    Pages 63-66
  8. L. Kovács, B. Lichardus
    Pages 67-78
  9. L. Kovács, B. Lichardus
    Pages 79-105
  10. L. Kovács, B. Lichardus
    Pages 106-113
  11. L. Kovács, B. Lichardus
    Pages 114-119
  12. L. Kovács, B. Lichardus
    Pages 120-122
  13. L. Kovács, B. Lichardus
    Pages 123-129
  14. L. Kovács, B. Lichardus
    Pages 130-130
  15. L. Kovács, B. Lichardus
    Pages 161-202
  16. L. Kovács, B. Lichardus
    Pages 203-211
  17. L. Kovács, B. Lichardus
    Pages 212-214
  18. L. Kovács, B. Lichardus
    Pages 215-246
  19. Back Matter
    Pages 247-296

About this book

Introduction

The mechanisms by which animals regulate the volume and composition of their body fluids has long had a particular fascination for students of biology. As a consequence, the subject can lay claim to an impressive record of ground­ breaking scientific achievements as well as a provocative body of philosophical speculation concerning the role of the system in the origin and evolution of life. Indeed, the entire concept of homeostasis on which so much of o~r current biologic thinking is based, derives from Claude Bernard's pioneering exploration of the forces that determine the composition of this 'internal sea'. Other seminal achievements credited to this area of inquiry include the first description of a genetically transmitted human disease (familial neurogenic diabetes insipidus); the first isolation sequencing and synthesis of a peptide hormone (vasopressin and oxytocin); the first demonstration of peptide hormone synthesis by way of a larger protein precursor; the first description of resistance to the biologic actions of a hormone (nephrogenic diabetes insipidus); and the conceptual realization of the unique counter-current mechanism that permits concentration of the urine. This record of far reaching and fundamental advances has been distinguished by many fruitful inter­ actions between clinical and basic science.

Keywords

Atmen Diabetes childhood homeostasis pregnancy

Authors and affiliations

  • L. Kovács
    • 1
  • B. Lichardus
    • 2
  1. 1.Department of PediatricsComenius University Medical SchoolBratislavaCzechoslovakia
  2. 2.Institute of Experimental EndocrinologyCenter of Physiological Sciences of the Slovak Academy of SciencesBratislavaCzechoslovakia

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-0449-1
  • Copyright Information Springer Science+Business Media B.V. 1989
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6686-0
  • Online ISBN 978-94-009-0449-1
  • Buy this book on publisher's site