Biological Models in Radiopharmaceutical Development

  • Richard M. Lambrecht

Part of the Developments in Nuclear Medicine book series (DNUM, volume 27)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Richard M. Lambrecht
    Pages 1-10
  3. Richard M. Lambrecht
    Pages 11-15
  4. Richard M. Lambrecht
    Pages 16-35
  5. Richard M. Lambrecht
    Pages 36-47
  6. Back Matter
    Pages 48-272

About this book


Radiophannaceuticals labeled with short-lived radionuclides are utilized to unravel biochemical processes, and to diagnosis and treat diseases of the living body are-developed through extensive evaluation in ~iological models. 'fhC first attempt to compile information was a volume entitled ANIMAL MODELS IN RADIOTRACER DESIGN that was edited by William C. Eckelman and myself in 1983. The volume had a focus on the animal models that investigators were using in order to design radiotracers that displayed in vivo selectivity as measured by biodistribution and pharmacokinetic studies. A concern in the early days of nuclear medicine was species differences. Often a series of labeled compounds were evaluated in a several different animal models in order to gain confidence that the selected radiotracer would behave appropriately in humans. During the past 12 years there have been remarkable advances in molecular genetics, molecular biology, synthetic radiopharmaceutical chemistry, molecular modeling and visualization, and emission tomography. Biological models can now be selected that are better defined in terms of molecular aspects of the disease process. The development of high resolution PET and SPET for clinical applications facilitates the development of new radiopharmaceuticals by the use of models to quantitatively evaluate drug effects, and progression of disease, and hence to arrive at better diagnosis and treatments for animals and humans. With these advances there is an effective use of biological models, and the refinement of alternatives for the development of new radiophannaceuticals.


chemistry drug drug development ethics poison positron emission tomography (PET) research screening

Authors and affiliations

  • Richard M. Lambrecht
    • 1
  1. 1.PET-Zentrum des UniversitätsklinikumsEberhard-Karls-Universität TübingenTübingenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1996
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6558-0
  • Online ISBN 978-94-009-0159-9
  • Buy this book on publisher's site