Vascular Medicine

From Endothelium to Myocardium

  • Ernst E. van der Wall
  • Volkert Manger Cats
  • Jan Baan

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 197)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Johan J. Schipperheijn
    Pages 1-11
  3. Peter W. H. M. Verheggen, Volkert Manger Cats
    Pages 23-31
  4. Jan Baan, Paul Steendijk, Jan Baan Jr.
    Pages 33-43
  5. Hubert W. Vliegen, J. Wouter Jukema, Arnoud van der Laarse, Hermann Haller
    Pages 45-53
  6. Han J. G. H. Mulder, Martin J. Schalij
    Pages 55-82
  7. Jeroen J. Bax, Ernst E. van der Wall
    Pages 83-101
  8. Johan H. C. Reiber, Bob Goedhart, Hans G. Bosch, Rob J. van der Geest, Jouke Dijkstra, Gerhard Koning et al.
    Pages 103-131
  9. Frits H. A. F. de Man, Mariëtte J. V. Hoffer, Augustinus H. M. Smelt, Jan A. Gevers Leuven, Arnoud van der Laarse
    Pages 133-160
  10. Louis M. Havekes, Bart J. M. van Vlijmen, Miek C. Jong, Pieter H. E. Groot, Ko Willems van Dijk, Marten H. Hofker
    Pages 161-173
  11. Tjeerd J. Römer, James F. Brennan III
    Pages 175-196
  12. Theo J. C. van Berkel, Miranda van Eck, Nicole Herijgers, Peter M. Hoogerbrugge, Pieter H. E. Groot
    Pages 197-218
  13. Back Matter
    Pages 219-233

About this book


Based on a number of collaborative efforts between basic researchers and clinicians from different institutions in Leiden, this book covers the initial and promising results of these efforts.
The role of the endothelium, especially of the coronary intravascular species is a relatively new and fascinating development in the diagnosis and treatment of cardiac disease. Three major aspects of endothelial function receive attention in this volume:
  • its regulatory role in myocardial function, evidence for which is gradually forthcoming, with possible great implications for disease states such as volume overload and failure
  • its role in the calcium metabolism of vascular smooth muscle cells and the effects of calcium antagonists and
  • the endothelial dysfunction generated by coronary angioplasty and its possible restoration by cholesterol reduction.

The topic of imaging atherosclerotic lesions in the coronary arteries is discussed with the emphasis on advanced methods: single photon emission computed tomography (SPECT), positron emission tomography (PET), and magnetic resonance imaging techniques. A wholly new development is the characterization of the atherosclerotic lesion by Raman spectroscopy using a laser beam to illuminate the vascular wall.
Various aspects of inflammation related to the pathogenesis of acute coronary syndromes, in particular unstable angina, are illuminated, as well as the role of blood-borne substances as risk factors for atherosclerosis. Transgenic mice carrying the gene for human APOE*3 Leiden are being used successfully to study the environmental and genetic factors that influence the remnant lipoprotein metabolism. Possibilities for gene therapy to treat atherosclerosis in the clinic are being investigated in animal models.
Finally, as the book is based on 50 years of Cardiology in Leiden, the history of its development up to the present day is the topic of a separate chapter. This book is intended for cardiologists, internal medicine specialists, nuclear medicine specialists, thoracic surgeons, cardiovascular radiologists and basic scientists in the field of the cardiovascular system.


Lipoprotein atherosclerosis cardiology cardiovascular cardiovascular system gene therapy

Editors and affiliations

  • Ernst E. van der Wall
    • 1
  • Volkert Manger Cats
    • 1
  • Jan Baan
    • 1
  1. 1.Department of CardiologyLeiden University Medical CentreLeidenThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1997
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6505-4
  • Online ISBN 978-94-009-0037-0
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site