Bone Metastases

A translational and Clinical Approach

  • Vassilios Vassiliou
  • Edward Chow
  • Dimitrios Kardamakis

Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 21)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Fundamental Concepts

    1. Front Matter
      Pages 1-1
    2. John M. Chirgwin, G. David Roodman
      Pages 3-17
    3. Vassilios Vassiliou, Edward Chow, Dimitrios Kardamakis, Natalie Lauzon
      Pages 19-36
    4. Elaine Wallace, Marissa Slaven, Marissa Slaven, Marissa Slaven, Richard Wennberg, Richard Wennberg et al.
      Pages 37-49
  3. Investigations of Bone Metastases

    1. Front Matter
      Pages 51-51
    2. Petros Polyviou, Demos Michaelides, Dimitrios Vomvas, Panteleimon Kountourakis, Vassilios Vassiliou, Dimitrios Andreopoulos
      Pages 53-70
    3. Andor W. J. M. Glaudemans, Alberto Signore
      Pages 71-94
    4. Janet E. Brown, Liang Zeng, Caroline Wilson
      Pages 95-124
  4. Therapeutic Management

    1. Front Matter
      Pages 155-155
    2. Sebastiano Mercadante
      Pages 157-173
    3. Candice Johnstone, Stephen T. Lutz
      Pages 175-185
    4. Fabio M. Paes
      Pages 187-215
    5. Grazia Armento, Marco Imperatori, Vladimir Virzì, Giuseppe Tonini, Daniele Santini
      Pages 217-234
    6. Allan Lipton, Luis Costa, Paul Sieber, William C. Dougall, Ada Braun
      Pages 235-246
    7. Konstantinos Kamposioras, Evangelos Briasoulis
      Pages 247-273
    8. Sheliza Halani, Jennifer Coccagna, Edward Chow, Kullervo Hynynen, Gregory J. Czarnota
      Pages 275-300
    9. Daniel Roos
      Pages 301-308
    10. Ernesto Maranzano, Fabio Trippa
      Pages 309-321
    11. Julian B. Sernik, Albert J. M. Yee, Markku T. Nousiainen
      Pages 323-340
    12. Peter Hoskin
      Pages 341-349
    13. Gillian Bedard, Liang Zeng, Erin Wong, Natalie Pulenzas, Breanne Lechner, Edward Chow
      Pages 351-363
    14. Vassilios Vassiliou, Panteleimon Kountourakis, Dimitrios Kardamakis
      Pages 365-379
  5. Assessment of Therapeutic Response

    1. Front Matter
      Pages 381-381
    2. Vassilios Vassiliou, Petros Polyviou, Dimitrios Andreopoulos, Savvas Frangos, Dimitrios Kardamakis
      Pages 383-405
    3. C. Roy, C. L. Addison, S. Mazzarello, I. Kuchuk, B. Hutton, M. Clemons
      Pages 407-417
    4. Michael Poon, Liang Zeng, Urban Emmenegger, Edward Chow
      Pages 419-439
    5. Marko Popovic, Liang Zeng, Edward Chow
      Pages 441-459
  6. Cost of Managing Metastatic Bone Disease

    1. Front Matter
      Pages 461-461
    2. Yvette M. van der Linden, Andre A. Konski
      Pages 463-480
  7. Back Matter
    Pages 481-490

About this book


The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases.

Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail.

Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.


Bone metastases Pain Quality of life Therapeutic response Treatment of bone metastases

Editors and affiliations

  • Vassilios Vassiliou
    • 1
  • Edward Chow
    • 2
  • Dimitrios Kardamakis
    • 3
  1. 1.Radiation OncologyBank of Cyprus Oncology CentreNicosiaCyprus
  2. 2.Dept. Radiation OncologyUniversity of Toronto Sunnybrook Health Sciences CentreTorontoCanada
  3. 3.Dept. Radiation OncologyUniversity of Patras Medical SchoolPatrasGreece

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-7568-8
  • Online ISBN 978-94-007-7569-5
  • Series Print ISSN 1568-2102
  • Buy this book on publisher's site