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Heat Shock Proteins of Malaria

  • Addmore Shonhai
  • Gregory L. Blatch

Table of contents

  1. Front Matter
    Pages i-viii
  2. Adrienne L. Edkins, Aileen Boshoff
    Pages 5-45
  3. Eva-Rachele Pesce, Alexander G. Maier, Gregory L. Blatch
    Pages 71-85
  4. Dea Shahinas, Dylan R. Pillai
    Pages 87-97
  5. Paul R. Gilson, Sarah C. Charnaud, Brendan S. Crabb
    Pages 99-117
  6. Evelyn Böttger, Gabriele Multhoff
    Pages 119-132
  7. Alassane Mbengue, Laurence Berry, Catherine Braun-Breton
    Pages 133-159
  8. Kaiyin Liu, Walid A. Houry
    Pages 161-187
  9. Manish Grover, Shweta Chaubey, Utpal Tatu
    Pages 189-205
  10. Back Matter
    Pages 213-223

About this book

Introduction

This book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer’s Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.

Keywords

Heat Shock Proteins and Chaperones Plasmodium falciparum malaria pathogenesis protein folding

Editors and affiliations

  • Addmore Shonhai
    • 1
  • Gregory L. Blatch
    • 2
  1. 1.Dept. of Biochemistry and MicrobiologyUniversity of ZululandKwaDlangezwaSouth Africa
  2. 2.College of Health and BiomedicineVictoria UniversityMelbourneAustralia

Bibliographic information