Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

  • Susan C. Frost
  • Robert McKenna

Part of the Subcellular Biochemistry book series (SCBI, volume 75)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Robert McKenna, Susan C. Frost
      Pages 3-5
  3. Carbonic Anhydrases: Ancient but Relevant

    1. Front Matter
      Pages 7-7
    2. Christopher D. Boone, Melissa Pinard, Rob McKenna, David Silverman
      Pages 31-52
    3. R. Siva Sai Kumar, James G. Ferry
      Pages 77-87
    4. Matthew S. Kimber
      Pages 89-103
    5. Holger M. Becker, Michael Klier, Joachim W. Deitmer
      Pages 105-134
    6. Ashok Aspatwar, Martti E. E. Tolvanen, Csaba Ortutay, Seppo Parkkila
      Pages 135-156
    7. Martin Benej, Silvia Pastorekova, Jaromir Pastorek
      Pages 199-219
    8. Narges K. Tafreshi, Mark C. Lloyd, Marilyn M. Bui, Robert J. Gillies, David L. Morse
      Pages 221-254
    9. Robert McKenna, Claudiu T. Supuran
      Pages 291-323
    10. Sally-Ann Poulsen, Rohan A. Davis
      Pages 325-347
    11. Andrea Scozzafava, Claudiu T. Supuran
      Pages 349-359
    12. Vincenzo Alterio, Simona Maria Monti, Giuseppina De Simone
      Pages 387-404
    13. Javier M. González, S. Zoë Fisher
      Pages 405-426
  4. Back Matter
    Pages 427-430

About this book



The study of carbonic anhydrase has spanned multiple generations of scientists.  Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton.  Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin.  Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments.

            The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms.  The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes.  The alpha class is found primarily in animals with several isoforms  associated with human disease.  The beta CAs are expressed primarily in plants and are the most divergent.  The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs.   The delta CAs are found in marine algae and diflagellates.  The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation.  

            With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity.  We have designed the book to cover basic information of mechanism, structure, and function of the CA families.  The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.


carbonic anhydrase industrial applications mechanism pathology structure

Editors and affiliations

  • Susan C. Frost
    • 1
  • Robert McKenna
    • 2
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of FloridaGainesvilleUSA
  2. 2.Department of Biochemistry and Molecular BiologyUniversity of FloridaGainesvilleUSA

Bibliographic information