Stem Cells and Cancer Stem Cells, Volume 11

Therapeutic Applications in Disease and injury

  • M.A. Hayat

Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 11)

Table of contents

  1. Front Matter
    Pages i-xxxviii
  2. Embryonic Stem Cells

  3. Cancer Stem Cells

    1. Front Matter
      Pages 65-65
    2. Lynnette Wei Hsien Koh, Tan Boon Toh, Carol Tang, Beng Ti Ang
      Pages 75-91
    3. Siddhartha Sen, Monica L. Guzman, Duane C. Hassane
      Pages 93-101
    4. Sampoorna Satheesha, Beat W. Schäfer
      Pages 111-126
    5. Hiroshi Murakami, Akifumi Mizutani, Chen Ling, Tomonari Kasai, Takayuki Kudoh, Li Fu et al.
      Pages 127-133
    6. Zhenhe Suo, Jian-Guo Wen, Jahn M. Nesland
      Pages 135-147
    7. Verena Kuchler, Euan S. Polson, Anjana Patel, Heiko Wurdak
      Pages 149-158
    8. Arokia Priyanka Vaz, Parthasarathy Seshacharyulu, Surinder K. Batra, Moorthy P. Ponnusamy
      Pages 171-185
  4. Hematopoietic Stem Cells

  5. Neural Stem Cells

    1. Front Matter
      Pages 231-231
    2. Martin M. Mortazavi, Nimer Adeeb, Aman Deep, R. Shane Tubbs
      Pages 233-240
    3. Martin M. Mortazavi, Nimer Adeeb, Aman Deep, R. Shane Tubbs
      Pages 241-252
  6. Back Matter
    Pages 265-280

About this book


Volume 11 in this series discusses therapeutic applications of stem cells in disease and tissue injury. Coverage includes pluripotent stem cells, which can give rise to the endodermal, ectodermal, and mesodermal lineages; multipotent stem cells, which can generate all cells in a particular lineage and unipotent stem cells, which can give rise to only one cell type. This volume also examines cancer stem cells, tumor-initiating cells which possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. Coverage extends to molecular mechanisms underlying the derivation and expansion of human embryonic stem cells, the role of specific proteins in the maintenance and inhibition of extraembryonic differentiation of these cells and the role of signaling responsible for the self-renewal of mouse embryonic stem cells. Nine chapters discuss the clinical importance of cancer stem cells, encompassing glioma, leukemia, ovarian cancer, pediatric sarcomas and head and neck squamous cell carcinoma. The role of cancer stem cells is also elucidated in epithelial-to-mesenchymal transition in spreading head and neck squamous cell carcinoma. The book goes on to survey therapeutic application of stem cells of hematopoietic and non-hematopoietic origin for regeneration of bones, including in osteoporotic bone disease; to illuminate the application of hematopoietic stem cells in bone regeneration and to discuss their use as a biomarker to facilitate determination of a treatment. The contributors review cells as biomarkers for pediatric solid tumors, and weigh the advantages and limitations of hematopoietic stem cell transplantation. Also included are details of neural stem cell engraftment in the injured spinal cord; the regenerative potential of neural stem/progenitor cells of newborns and cancer gene therapy potential using neural stem cells. Like the preceding volumes in the series, this book is distinguished for its comprehensive approach, its distinguished roster of 58 contributors representing 10 different countries and its thorough review of leading-edge technology and methods.


Cancer Cell-based Therapy Clinical therapies Regeneration Medicine Targeted therapy

Editors and affiliations

  • M.A. Hayat
    • 1
  1. 1.Department of Biological SciencesKean university, Room 213, Library BuildingUnionUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-7328-8
  • Online ISBN 978-94-007-7329-5
  • Series Print ISSN 2215-0994
  • Series Online ISSN 2215-1001
  • Buy this book on publisher's site