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Proteins and Proteomics of Leishmania and Trypanosoma

  • André L.S. Santos
  • Marta H. Branquinha
  • Claudia M. d’Avila-Levy
  • Lucimar F. Kneipp
  • Cátia L. Sodré

Part of the Subcellular Biochemistry book series (SCBI, volume 74)

Table of contents

  1. Front Matter
    Pages i-x
  2. Juliany Cola Fernandes Rodrigues, Joseane Lima Prado Godinho, Wanderley de Souza
    Pages 1-42
  3. Despina Smirlis, Milena Botelho Pereira Soares
    Pages 43-76
  4. Ana Paula Fernandes, Adriana Monte Cassiano Canavaci, Laura-Isobel McCall, Greg Matlashewski
    Pages 77-101
  5. Maria Fernanda Laranjeira da Silva, Lucile Maria Floeter-Winter
    Pages 103-117
  6. Turán P. Ürményi, Rosane Silva, Edson Rondinelli
    Pages 119-135
  7. Cristian Cortez, Tiago J. P. Sobreira, Fernando Y. Maeda, Nobuko Yoshida
    Pages 137-150
  8. Eliciane C. Mattos, Renata R. Tonelli, Walter Colli, Maria Julia M. Alves
    Pages 151-180
  9. Isadora A. Oliveira, Leonardo Freire-de-Lima, Luciana L. Penha, Wagner B. Dias, Adriane R. Todeschini
    Pages 181-201
  10. Sergio Steven Cornejo Rubin De Celis
    Pages 203-216
  11. Anita Leocadio Freitas-Mesquita, José Roberto Meyer-Fernandes
    Pages 217-252
  12. Claudia M. d’Avila-Levy, Ellen C. F. Altoé, Lívia A. Uehara, Marta H. Branquinha, André L. S. Santos
    Pages 253-270
  13. Jose Batista de Jesus, Camila Mesquita-Rodrigues, Patricia Cuervo
    Pages 323-349
  14. Fabricio K. Marchini, Lyris Martins Franco de Godoy, Michel Batista, Fernanda G. Kugeratski, Marco A. Krieger
    Pages 351-378
  15. Back Matter
    Pages 379-381

About this book

Introduction

This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteome of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.

Keywords

Chemotherapy Leishmania Protein Proteomic Trypanosoma

Editors and affiliations

  • André L.S. Santos
    • 1
  • Marta H. Branquinha
    • 2
  • Claudia M. d’Avila-Levy
    • 3
  • Lucimar F. Kneipp
    • 4
  • Cátia L. Sodré
    • 5
  1. 1.Departamento de Microbiologia GeralInstituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de JaneiroRio de JaneiroBrazil
  2. 2.Departamento de Microbiologia GeralIns. de Microbiologia Paulo de Góes, Universidade Federal do Rio de JaneiroRio de JaneiroBrazil
  3. 3.Fundação Oswaldo CruzRio de JaneiroBrazil
  4. 4.Fundação Oswaldo CruzRio de JaneiroBrazil
  5. 5.Departamento de Biologia Celular e MolecularInstituto de Biologia Universidade Federal FluminenseNiteróiBrazil

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-7305-9
  • Copyright Information Springer Science+Business Media Dordrecht 2014
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-7304-2
  • Online ISBN 978-94-007-7305-9
  • Series Print ISSN 0306-0225
  • Buy this book on publisher's site