Evolution-adjusted Tumor Pathophysiology:

The Novel Language of Tumor Biology

  • Albrecht Reichle

Table of contents

  1. Front Matter
    Pages i-x
  2. Introduction

  3. Combined Modularized Therapies for Metastatic Tumors: Pointing to Central Problems of Communication Among ‘Systems Participators’ in Tumors

  4. Social Engineering: Biomodulation, Either Endogenously Initiated or by Implementation of Non-normative Boundary Conditions

  5. The Tumors’ Normativity: Reconstructing and Operationalizing Starting Points for an Evolution Theory

  6. Evolution Theory

  7. From Genome- or Organ-centric to Rationalization-centric Systematization of Tumors

  8. Reconstruction of Tumor-Immanent Normative Functions, Structures and Decision Maxims (Hubs)

  9. The Tool of Rationalizations Constituting Tumor-Associated Normative Notions: The Non-Genomic Counterpart of the Tumor Genome and Therefore, an Important Therapeutic Target for Diversifying Palliative Care

  10. Novel Clinical and Pharmaceutical Technology for Bioengineering Tumor Response

  11. Objectifying the Systems Objects’ Subjectivity in Biological Systems: A Novel Reification of the Scientific Picture About the ‘Objective’ World

    1. Front Matter
      Pages 431-431
  12. Back Matter
    Pages 439-453

About this book


Combined modularized therapies for metastatic cancer are pointing to central problems of communication among ‘systems participators’. A communication theory explains 'social engineering', endogenously induced or by implementing non-normative boundary conditions. Evolution-adjusted tumor pathophysiology is borne by an evolution theory, which contrasts narrative evolution histories. The tool of rationalizations constituting the tumor's normativity (inflammation, immune response etc.) represents the non-genomic counterpart of the tumor genome and should be additionally assessed during tumor staging. Evolution-adjusted tumor pathophysiology allows implementing applied systems biology, a novel clinical and pharmaceutical technology for bioengineering tumor response and personalizing tumor therapy. Combined modularized therapy, evolution-adjusted tumor pathophysiology, and ‘universal’ biomarkers concertedly address genetically based tumor heterogeneity.


Biomodulatory tumor therapy Communication theory Evolution theory Philosophy Tumor pathophysiology

Editors and affiliations

  • Albrecht Reichle
    • 1
  1. 1., Department of Hematology and OncologyUniversity Hospital RegensburgRegensburgGermany

Bibliographic information