Transcriptional and Translational Regulation of Stem Cells

  • Gary Hime
  • Helen Abud
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 786)

Table of contents

  1. Front Matter
    Pages i-x
  2. Gary R. Hime, Helen E. Abud
    Pages 1-4
  3. Corey Heffernan, Jun Liu, Huseyin Sumer, Luis F. Malaver-Ortega, Rajneesh Verma, Edmund Carvalho et al.
    Pages 5-25
  4. Model Stem Cell Systems (A) Invertebrate

    1. Front Matter
      Pages 27-27
    2. Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter, Judith Kimble
      Pages 29-46
    3. Xiankun Zeng, Chhavi Chauhan, Steven X. Hou
      Pages 63-78
  5. Model Stem Cell Systems (B) Vertebrate

    1. Front Matter
      Pages 103-103
    2. Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate, Ann M. Turnley
      Pages 129-155
    3. Briana Lee, Xing Dai
      Pages 157-173
    4. Katja Horvay, Helen E. Abud
      Pages 175-186
    5. Adam C. Wilkinson, Berthold Göttgens
      Pages 187-212
    6. David Cook, Paul Genever
      Pages 213-229
  6. Molecular Families Implicated in Stem Cell Regulation

    1. Front Matter
      Pages 231-231
    2. Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime, Nicole A. Siddall
      Pages 233-245
    3. Rachel R. Stine, Erika L. Matunis
      Pages 247-267
    4. Leonie M. Quinn, Julie Secombe, Gary R. Hime
      Pages 269-285
    5. Qin Wang, Austin J. Cooney
      Pages 287-306

About this book

Introduction

Stem cells are central to the development and homeostasis of metazoan tissues and play roles at multiple times within a diversity of organs during the lifetime of an animal. A key goal of regenerative medicine is the in vivo repair of organs damaged by disease or injury.  In order to facilitate this goal we need to understand how stem cells are generated, what factors maintain them in their respective tissues and how their differentiation is regulated. In this volume, leading researchers discuss the nature of stem cells and pluripotency and how this state can be experimentally induced.  Stem cell maintenance, proliferation and differentiation is under tight regulation as excess stem cell proliferation could facilitate tumour formation and conversely loss of stem cells or failure of  differentiation could disrupt tissue homeostasis or  repair. Hence, stem cells are regulated by multiple layers of molecular control and this volume discusses transcriptional, translational, epigenetic, cell signalling and microRNA modalities that affect stem cell behaviour. Many of the underlying key principles of stem cell biology were discovered by genetic analysis of invertebrate systems and chapters in this volume describe regulation of the germline in C. elegans and in the digestive system, central nervous system and germline of Drosophila. The molecular processes that regulate regenerative organ systems from all three of the vertebrate germ layers are described with emphasis on the male germline, nervous system, epidermis, intestine, haematopoietic system and derivatives of the mesoderm. Several chapters also focus on molecular families that have been implicated in controlling a range of stem cell types including the JAK-STAT, Wnt and  Notch signalling pathways; Myc, Myb and nuclear receptor transcriptional regulators; the Musashi family of RNA-binding proteins; microRNAs and epigenetic regulators.

This volume will provide access to the current state of research in these rapidly evolving areas of stem cell biology to the student, educator or researcher.

Keywords

epigenetic microRNAs stem cells transcription translation

Editors and affiliations

  • Gary Hime
    • 1
  • Helen Abud
    • 2
  1. 1., Anatomy and NeuroscienceUniversity of MelbourneParkvilleAustralia
  2. 2., Anatomy and Developmental BiologyMonash UniversityClaytonAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-6621-1
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-6620-4
  • Online ISBN 978-94-007-6621-1
  • Series Print ISSN 0065-2598
  • About this book