Pediatric Cancer, Volume 4

Diagnosis, Therapy, and Prognosis

  • M.A. Hayat

Part of the Pediatric Cancer book series (PECA, volume 4)

Table of contents

  1. Front Matter
    Pages i-xxxvi
  2. Neuroblastoma

    1. Front Matter
      Pages 1-1
    2. Yania Yañez, Elena Grau, Adela Cañete, Victoria Castel
      Pages 3-10
    3. Sara Cattelani, Giovanna Ferrari-Amorotti, Angela Rachele Soliera, Gloria Manzotti, Giuseppe Raschellà, Bruno Calabretta
      Pages 19-25
    4. Salvador Meseguer, Emilio J. Laserna, Juan Manuel Escamilla, Susana Masiá, Domingo Barettino
      Pages 37-47
    5. Maria Valeria Corrias, Michela Croce, Marina Fabbi
      Pages 49-55
    6. Manuele Castelnuovo, Tullio Florio, Giorgio Dieci, Ranieri Cancedda, Aldo Pagano
      Pages 57-66
  3. Medulloblastoma

    1. Front Matter
      Pages 79-79
    2. Peter Hauser, Dezső Schuler, Miklos Garami
      Pages 81-91
  4. Leukemia

    1. Front Matter
      Pages 103-103
    2. Nan Jiang, Grace Shimin Koh, Allen Eng Juh Yeoh
      Pages 113-120
    3. Elio Castagnola, Malgorzata Mikulska, Francesca Ginocchio, Claudio Viscoli
      Pages 121-138
  5. Lymphoma

    1. Front Matter
      Pages 153-153

About this book

Introduction

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children. The contents are organized in seven sections: Neuroblastoma, Medulloblastoma, Leukemia, Lymphoma, Rhabdoid, Sarcoma and Miscellaneous Tumors.

Coverage includes pediatric medulloblastoma, and treatments including craniospinal radiation followed by adjuvant chemotherapy. The contributors explain diagnosis and chemotherapy of children with acute lymphoblastic leukemia, and diagnosis of bone marrow involvement in pediatric lymphoma patients. Ewing’s sarcoma, a highly malignant connective tissue neoplasm formed by the proliferation of mesenchymal cells, receives extensive coverage, including targeting of molecular pathways and chemotherapy and surgical treatment. The roles of apoptotic genes, MYCN gene, MDM2, and SNP309, P13K inhibitors, alternative splicing and microRNAs, activated leukocyte cell adhesion molecule and inhibition by alu-like RNA in neuroblastoma are discussed in detail.

The book explores the molecular genetics, diagnosis, prognosis and therapy of the atypical teratoid/rhabdoid tumor (AT/RT). Among the most common malignant neoplasms in children, AT/RT exhibits similarities with other CNS tumors, which can lead to misclassification, as pointed out in the book. The contributors discuss diagnosis of AT/RT type using imaging technology, and describe new strategies, including intensive multimodal therapy and high dose chemotherapy with autologous stem cell transplantation that have shown improved outcomes. Coverage of therapies includes total resection followed by aggressive chemotherapy and radiation.

Discussion includes diagnosis and treatment of other pediatric tumors including adrenocortical tumors, supratentorial primitive neuroectodermal tumors, giant midline tumors, gastrointestinal stromal tumors, ependymomas and intramedullary cavernoma.

Pediatric Cancer: Diagnosis, Therapy and Prognosis, Volume 4 includes contributions by ninety-one contributors - oncologists, neurosurgeons, physicians, research scientists and pathologists - representing thirteen countries.

The editor, M.A. Hayat, is a Distinguished Professor in the Department of Biological Sciences at Kean University, Union, New Jersey, USA.

Keywords

Children's cancer Genetic defects in cancer Survival after cancer treatment Treatments for cancer Types of children's cancer

Editors and affiliations

  • M.A. Hayat
    • 1
  1. 1., Kean UniversityRoom 213, Library buildingUnionUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-6591-7
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-6590-0
  • Online ISBN 978-94-007-6591-7
  • Series Print ISSN 2211-7997
  • Series Online ISSN 2211-8004
  • About this book