Advancing Methods for Biomolecular Crystallography

  • Randy Read
  • Alexandre G. Urzhumtsev
  • Vladimir Y. Lunin

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Todd O. Yeates
    Pages 23-31
  3. Kay Diederichs, P. Andrew Karplus
    Pages 59-68
  4. Elspeth F. Garman, Oliver B. Zeldin
    Pages 79-89
  5. Tatiana Petrova, Vladimir Y. Lunin, Stephan Ginell, Andre Mitschler, Youngchang Kim, Grazyna Joachimiak et al.
    Pages 91-103
  6. Randy J. Read, Airlie J. McCoy, Robert D. Oeffner, Gábor Bunkóczi
    Pages 113-122
  7. Isabel Usón, Claudia Millán, Massimo Sammito, Kathrin Meindl, Iñaki M. de Ilarduya, Ivan De Marino et al.
    Pages 123-133
  8. Zbigniew Dauter
    Pages 135-149
  9. Vladimir Y. Lunin, Natalia L. Lunina, Alexandre G. Urzhumtsev
    Pages 181-192

About these proceedings

Introduction

This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web.  Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis.  These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome.  Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.

Keywords

Automated structural biology Erice crystallography course Protein crystallography

Editors and affiliations

  • Randy Read
    • 1
  • Alexandre G. Urzhumtsev
    • 2
  • Vladimir Y. Lunin
    • 3
  1. 1., Department of HaematologyUniversity of CambridgeCambridgeUnited Kingdom
  2. 2.Fac.des Sciences et des Technologies, Physics DepartmentUniversité de LorraineVandoeuvre-lès-NancyFrance
  3. 3., Institute of Mathematical Problems of BiRussian Academy of SciencesPushchinoRussia

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-6232-9
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-94-007-6231-2
  • Online ISBN 978-94-007-6232-9
  • Series Print ISSN 1874-6489
  • Series Online ISSN 1874-6527
  • About this book