The Tumor Immunoenvironment

  • Michael R. Shurin
  • Viktor Umansky
  • Anatoli Malyguine

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Anatoli Malyguine, Viktor Umansky, Michael R. Shurin
    Pages 1-12
  3. Tumor Microenvironment and Immunoenvironment

    1. Front Matter
      Pages 13-13
    2. Shelly Maman, Isaac P. Witz
      Pages 15-38
    3. Maria Libera Ascierto, Francesco M. Marincola, Ena Wang
      Pages 83-104
  4. Developmental Characteristics of the Tumor Immunoenvironment

    1. Front Matter
      Pages 105-105
    2. M. J. P. Welters, S. H. van der Burg
      Pages 107-133
    3. Tal Leibovich-Rivkin, Yaeli Lebel-Haziv, Shalom Lerrer, Polina Weitzenfeld, Adit Ben-Baruch
      Pages 135-175
    4. Suzanne Ostrand-Rosenberg, Pratima Sinha
      Pages 177-196
    5. Annie Mirsoian, Gail D. Sckisel, Anthony E. Zamora, William J. Murphy
      Pages 223-250
  5. Tumor Escape from Immune Recognition

    1. Front Matter
      Pages 251-251
    2. Natalia Aptsiauri, Teresa Cabrera, Angel Garcia-Lora, Francisco Ruiz-Cabello, Federico Garrido
      Pages 253-286
    3. Mads Hald Andersen, Jürgen C. Becker, Per thor Straten
      Pages 287-306
    4. Yutaka Kawakami, Tomonori Yaguchi, Hidetoshi Sumimoto, Chie Kudo-Saito, Nobuo Tsukamoto, Tomoko Iwata-Kajihara et al.
      Pages 307-323
    5. Eitan Yefenof
      Pages 325-338
    6. Yong Lu, Jing Yang, Qing Yi
      Pages 339-360
  6. Immune Regulators in the Tumor Immunoenvironment

    1. Front Matter
      Pages 383-383
    2. Stephanie K. Watkins, Arthur A. Hurwitz
      Pages 431-455
    3. Zvi G. Fridlender
      Pages 457-478
    4. Sharon A. Oldford, Jean S. Marshall
      Pages 479-509
    5. Theresa L. Whiteside
      Pages 511-523
    6. Catalina Lee-Chang, Monica Bodogai, Arya Biragyn
      Pages 525-546
  7. Tumor Escape and Cancer Immunotherapy

    1. Front Matter
      Pages 547-547
    2. Philipp Beckhove
      Pages 549-565
    3. Peter Svider, Shu-Hsia Chen, Andrew G. Sikora, Wen-Chin Yang
      Pages 567-584
    4. Wei Wang, Weiping Zou
      Pages 585-602
    5. Michael R. Shurin, Viktor Umansky
      Pages 603-619
    6. Nishith Singh, James Hodge, Ravi Madan, James L. Gulley
      Pages 621-642
    7. Pamela L. Beatty, Olivera J. Finn
      Pages 643-660
  8. Analyzing Immune Responses in Cancer

    1. Front Matter
      Pages 661-661
    2. Lisa H. Butterfield, Lazar Vujanovic, Angela D. Pardee
      Pages 663-694
    3. Anatoli Malyguine, Kimberly Dunham, Thomas J. Sayers, Michael R. Shurin
      Pages 695-706
    4. Peiyuan Zhu, Yevgeniya V. Segal, Galina V. Shurin, Michael R. Shurin
      Pages 707-723
  9. Back Matter
    Pages 741-745

About this book


Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this interaction and orchestrating multiple events in the tumor microenvironment. The balance between immune cells that support tumor progression and immune cells that sustain tumor-controlling immune surveillance is tightly regulated by various factors originated from both the malignant and non-cancerous cells in the tumor microenvironment. Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor ImmunoEnvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions. Moreover, it is discussed how these interactions evolve during cancer progression and in response to different kinds of anticancer therapy. It is anticipated that the book will attract many researchers and clinicians in the field of basic and applied tumor immunobiology and open new opportunities for collaborative programs aiming at the development of effective and feasible therapeutic approaches to cancer treatment.


Cancer immunomonitoring Cancer immunotherapy Cancer-mediated immunomodulation Tumor immunobiology Tumor microenvironment

Editors and affiliations

  • Michael R. Shurin
    • 1
  • Viktor Umansky
    • 2
  • Anatoli Malyguine
    • 3
  1. 1.Department of PathologyUniversity of Pittsburgh Medical CenterPittsburghUSA
  2. 2., Clinical Cooperation Unit Dermato-OncoloGerman Cancer Research CenterHeidelbergGermany
  3. 3., SAIC-Frederick, Inc.National Cancer Institute at FrederickFrederickUSA

Bibliographic information