Tumor Dormancy, Quiescence, and Senescence, Volume 1

Aging, Cancer, and Noncancer Pathologies

  • M.A. Hayat

Part of the Tumor Dormancy and Cellular Quiescence and Senescence book series (DOQU, volume 1)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. Tumor Dormancy

    1. Front Matter
      Pages 1-1
    2. Dieter Hölzel, Renate Eckel, Rebecca Emeny, Jutta Engel
      Pages 7-21
    3. George R. Nahas, Jacqueline M. Park, Pranela Rameshwar
      Pages 23-33
    4. Jacqui Shaw, Kevin Blighe, Karen Page, David Guttery, R. Charles Coombes
      Pages 35-50
    5. Vincent L. Morris, Dean B. Percy, Michael M. Lizardo, Ann F. Chambers, Ian C. MacDonald
      Pages 63-78
  3. Quiescence

  4. Cellular Senescence

    1. Front Matter
      Pages 127-127
    2. Peter J. Hornsby
      Pages 129-139
    3. Seunghee Lee, Ji-Won Jung, Kyung-Sun Kang
      Pages 207-214
    4. Sayuri Fukui, Masaki Sekiguchi, Kenichi Miyata, Hiroaki Ohdaira, Kenichi Yoshida
      Pages 269-280
    5. Hiroshi Kondoh, Takumi Mikawa, Matilde E. LLeonart
      Pages 281-289
  5. Back Matter
    Pages 317-324

About this book


With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic.

Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.


Chemotherapy and Radiation treatments Genertic and epgenetic factors causing cancer Is tumor dormancy clinically relevant? Treatment of different cancer types Understanding neurodegeneration

Editors and affiliations

  • M.A. Hayat
    • 1
  1. 1., Kean UniversityRoom 213, Library buildingUnionUSA

Bibliographic information