Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future

  • Silvia Mandel

Part of the Advances in Predictive, Preventive and Personalised Medicine book series (APPPM, volume 2)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Part I

  3. Part II

  4. Part III

    1. Front Matter
      Pages 93-93
    2. Iris Grossman, Michael W. Lutz, Donna G. Crenshaw, Ann M. Saunders, Ornit Chiba-Falek, William K. Gottschalk et al.
      Pages 141-160
    3. Peter A. LeWitt, Bertrand R. Huber, Jing Zhang
      Pages 161-184
  5. Part IV

    1. Front Matter
      Pages 185-185
  6. Part V

    1. Front Matter
      Pages 203-203
    2. Chen Benkler, Daniel Offen, Eldad Melamed, Tamar Amit, Silvia Mandel, Moussa B. H. Youdim et al.
      Pages 235-274
  7. Part VI

    1. Front Matter
      Pages 275-275
    2. Andrea Döring, Caspar F. Pfueller, Friedemann Paul, Jan Dörr
      Pages 277-299
  8. Part VII

    1. Front Matter
      Pages 309-309
    2. Rosella Tomanin, Cinzia Maria Bellettato, Francesca D’Avanzo, Alessandra Zanetti, Adriana Ceci, David Begley et al.
      Pages 311-327
  9. Back Matter
    Pages 329-396

About this book


The economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments.

This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.


Neurodegenerative diseases Neuropsychiatric diseases Personalized treatment Predictive diagnosis Preventive measures

Editors and affiliations

  • Silvia Mandel
    • 1
  1. 1., Molecular PharmacologyTechnion, Institute of TechnologyHaifaIsrael

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-94-007-5865-0
  • Online ISBN 978-94-007-5866-7
  • Series Print ISSN 2211-3495
  • Series Online ISSN 2211-3509
  • Buy this book on publisher's site