Cancer Genomics

Molecular Classification, Prognosis and Response Prediction

  • Ulrich Pfeffer

Table of contents

  1. Front Matter
    Pages i-vi
  2. Kenneth J. Craddock, Shirley Tam, Chang-Qi Zhu, Ming-Sound Tsao
    Pages 1-46
  3. J. Tímár, T. Barbai, B. Győrffy, E. Rásó
    Pages 47-78
  4. Michael Zeschnigk, Dietmar R. Lohmann
    Pages 79-96
  5. Thomas J. Belbin, Roberto A. Lleras, Richard V. Smith, Nicolas F. Schlecht, Jihyeon Lim, Thomas M. Harris et al.
    Pages 97-130
  6. Lara Lipton, Michael Christie, Oliver Sieber
    Pages 131-162
  7. Rosina Maria Critelli, Elisabetta Cariani, Erica Villa
    Pages 163-184
  8. George M. Yousef, Nicole M. A. White, Andrew H. Girgis
    Pages 185-217
  9. Vincenzo Corbo, Andrea Mafficini, Eliana Amato, Aldo Scarpa
    Pages 219-253
  10. Ulrich Pfeffer, Valentina Mirisola, Alessia Isabella Esposito, Adriana Amaro, Giovanna Angelini
    Pages 255-294
  11. Delia Mezzanzanica, Loris De Cecco, Marina Bagnoli, Patrizia Pinciroli, Marco A. Pierotti, Silvana Canevari
    Pages 295-348
  12. M. Angeles López-García, Begoña Vieites, M. Angeles Castilla, Laura Romero-Pérez, Juan Díaz-Martín, Michele Biscuola et al.
    Pages 349-390
  13. Frédéric Chibon, Alain Aurias, Jean-Michel Coindre
    Pages 429-452
  14. Sabina Chiaretti, Robin Foà
    Pages 453-493
  15. Francesco Bertoni, Zhi-Ming Li, Emanuele Zucca
    Pages 495-541
  16. Back Matter
    Pages 583-588

About this book

Introduction

The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with  its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case.

Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first  ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident. 

Keywords

cancer genomics copy number variation gene expression profiling molecular classification prognostic signatures

Editors and affiliations

  • Ulrich Pfeffer
    • 1
  1. 1., Integrated Molecular PathologyNational Cancer Research InstituteGenovaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-5842-1
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-5841-4
  • Online ISBN 978-94-007-5842-1
  • About this book