Central Nervous System Metastasis, the Biological Basis and Clinical Considerations

  • DianeĀ Palmieri

Part of the Cancer Metastasis - Biology and Treatment book series (CMBT, volume 18)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Diane Palmieri
    Pages 1-13
  3. Stephan Woditschka, Brunilde Gril, Lynda M. Evans, L. Tiffany Reed, Patricia S. Steeg
    Pages 15-41
  4. Mami Noda
    Pages 43-54
  5. Chris E. Adkins, Rajendar K. Mittapalli, Kaci A. Bohn, Amit Bansal, Vinay K. Venishetty, Paul R. Lockman
    Pages 55-68
  6. Amanda M. Hamilton, Paula J. Foster
    Pages 69-86
  7. Douglas L. Stofko, Robert J. Weil, Steven A. Toms
    Pages 109-132
  8. DeeDee Smart
    Pages 153-186
  9. Priscilla K. Brastianos, Charilaos H. Brastianos, April F. Eichler
    Pages 187-200
  10. Lauren A. Chandler, Kathleen L. Fuchs
    Pages 201-219
  11. Back Matter
    Pages 221-226

About this book


This volume covers what is known regarding the natural history, basic biology, and clinical aspects, including imaging and treatment, of CNS metastasis. Three chapters cover the biology of the brain and brain metastases: molecular biology, includes what is known about specific genes/proteins involved in the process of metastasis and model systems to study brain metastasis; brain microenvironment, focuses on the resident cells of the microenvironment and their role in CNS metastasis; and the blood-brain barrier, includes a discussion of permeability with respect to brain metastases. A discussion of experimental imaging covers both the biology of brain metastasis from an imaging perspective and the use of imaging techniques to study brain metastases. The three clinical chapters discuss treatment options of surgery, chemotherapy, and radiation. The potential for novel targeted therapies is also addressed. Because of the uniqueness of the disease, leptomeningeal metastasis is discussed separately. The last chapter is devoted to quality of life issues associated with CNS metastasis.


Biology Brain CNS Metastasis Metastasis

Editors and affiliations

  • DianeĀ Palmieri
    • 1
  1. 1., Laboratory of Molecular PharmacologyNational Cancer InstituteBethesdaUSA

Bibliographic information