Novel Apoptotic Regulators in Carcinogenesis

  • George G. Chen
  • Paul B.S. Lai

Table of contents

  1. Front Matter
    Pages i-xi
  2. Azman Seeni, Nur Ayunie Zulkepli, Ridhwan Abdul Wahab
    Pages 1-25
  3. Ahmed Kamal, Adla Mallareddy, Paidakula Suresh
    Pages 45-92
  4. Jairam Vanamala, Sridhar Radhakrishnan, Lavanya Reddivari, Aaron Massey
    Pages 93-122
  5. Simona Serini, Elena Fasano, Elisabetta Piccioni, Achille Renato Maria Cittadini, Gabriella Calviello
    Pages 123-147
  6. Dongyun Zhang, Chuanshu Huang
    Pages 149-187
  7. Danielle D. Jandial, Anne R. Simoneau, Xiaolin Zi
    Pages 189-204
  8. Subhadeep Das, Malay Chatterjee
    Pages 227-245
  9. Jennifer Yang, Gregory B. Lesinski
    Pages 247-266
  10. Back Matter
    Pages 289-299

About this book

Introduction

Our recent understanding of the cellular and molecular defects and the regulation of the apoptotic signalling pathways has resulted in rationally designed anticancer strategies and the development of novel agents that regulates apoptosis. A comprehensive review of all apoptotic-related anticancer therapies is not the purpose of this book. However, in the volume of this book with 11 chapters, we have described a number of novel apoptotic regulators that have shown promising value and also great feasibility for cancer treatment. These novel agents either occur naturally or are chemically synthesized. While we are excited about the discovery and development of these novel apoptotic regulators as potential anticancer agents, a degree of caution should be always borne in mind when interpreting the success of preclinical pro-apoptotic candidates since potential problems inevitably lie ahead. These problems usually include target specificity, unanticipated toxicity, compound stability, formulation issues, pharmacokinetic and pharmacodynamic profiles. Nevertheless, we believe that this collection of 11 chapters by established leaders in the area of apoptosis will be of great interest to not only academics working in the field of cancer research and apoptosis but also pharmaceutical and pharmacological industries that . We are looking forward to the further development to push these potential agents toward clinical stage.

Keywords

Apoptosis Cancer treatment Carcinogenesis Novel agents

Editors and affiliations

  • George G. Chen
    • 1
  • Paul B.S. Lai
    • 2
  1. 1., SurgeryThe Chinese University of Hong KongHong KongHong Kong SAR
  2. 2., SurgeryThe Chinese University of Hong KongHong KongHong Kong SAR

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-4917-7
  • Copyright Information Springer Science+Business Media Dordrecht 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-4916-0
  • Online ISBN 978-94-007-4917-7
  • About this book