Modelling of GPCRs

A Practical Handbook

  • Andrea Strasser
  • Hans-Joachim Wittmann

Table of contents

  1. Front Matter
    Pages 1-1
  2. Andrea Strasser, Hans-Joachim Wittmann
    Pages 1-4
  3. Andrea Strasser, Hans-Joachim Wittmann
    Pages 5-11
  4. Andrea Strasser, Hans-Joachim Wittmann
    Pages 13-28
  5. Andrea Strasser, Hans-Joachim Wittmann
    Pages 29-36
  6. Andrea Strasser, Hans-Joachim Wittmann
    Pages 37-58
  7. Andrea Strasser, Hans-Joachim Wittmann
    Pages 59-73
  8. Andrea Strasser, Hans-Joachim Wittmann
    Pages 75-103
  9. Andrea Strasser, Hans-Joachim Wittmann
    Pages 105-120
  10. Andrea Strasser, Hans-Joachim Wittmann
    Pages 121-129
  11. Andrea Strasser, Hans-Joachim Wittmann
    Pages 131-138
  12. Andrea Strasser, Hans-Joachim Wittmann
    Pages 139-159
  13. Back Matter
    Pages 13-13

About this book

Introduction

G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book “Modelling of GPCRs – a practical handbook” is focussed onto a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in GPCR modelling, but also addresses the advanced GPCR modeller: On the one hand, the book introduces  principles of GPCR modelling, including extensive examples. On the other hand, detailed outlooks onto advanced GPCR modelling techniques are presented. Furthermore, the book includes important data, like information about crystal structures in a summarized manner or amino acid sequences, which are essential for GPCR modelling in general. Due to an increase in efficacy and data handling most modellers use LINUX as operating system. To address this, a summary of most important LINUX commands with examples is presented within the book.

Keywords

GPCR Molecular Dynamics Molecular Modelling Receptor Modelling

Authors and affiliations

  • Andrea Strasser
    • 1
  • Hans-Joachim Wittmann
    • 2
  1. 1., Institute of PharmacyUniversity of RegensburgRegensburgGermany
  2. 2., Faculty of Chemistry and PharmacyUniversity of RegensburgRegensburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-4596-4
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-4595-7
  • Online ISBN 978-94-007-4596-4
  • About this book