DNA Repair of Cancer Stem Cells

  • Lesley A Mathews
  • Stephanie M Cabarcas
  • Elaine M. Hurt

Table of contents

  1. Front Matter
    Pages 1-1
  2. Chengzhuo Gao, Robert E. Hollingsworth, Elaine M. Hurt
    Pages 1-18
  3. Thomas S. Dexheimer
    Pages 19-32
  4. Olga Momčilović, Gerald Schatten
    Pages 53-87
  5. Monica Venere, Jeremy N. Rich, Shideng Bao
    Pages 89-103
  6. Hong Yin, Jonathan Glass
    Pages 105-124
  7. Lesley A. Mathews, Francesco Crea, Marc Ferrer
    Pages 157-172
  8. Stephanie M. Cabarcas
    Pages 173-175
  9. Back Matter
    Pages 173-173

About this book

Introduction

The existence of ‘cancer stem cells’ (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence.  CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise.

To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types. 

Keywords

Cancer Stem Cells DNA Repair Drug Resistance Tumor Initiating Cells qHTS Screening

Editors and affiliations

  • Lesley A Mathews
    • 1
  • Stephanie M Cabarcas
    • 2
  • Elaine M. Hurt
    • 3
  1. 1.Division of Pre-Clinical Innovation, Nat. Center for Advancing Transl. ScieNational Institutes of HealthRockvilleUSA
  2. 2.Gannon UniversityErieUSA
  3. 3.Preclinical Oncology ResearchGaithersburgUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-4590-2
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-4589-6
  • Online ISBN 978-94-007-4590-2
  • About this book