The Eukaryotic Replisome: a Guide to Protein Structure and Function

  • Stuart MacNeill
Part of the Subcellular Biochemistry book series (SCBI, volume 62)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Stephen J. Aves, Yuan Liu, Thomas A. Richards
    Pages 19-35
  3. Stephen D. Bell
    Pages 59-69
  4. Christophe Caillat, Anastassis Perrakis
    Pages 71-87
  5. Ian M. Slaymaker, Xiaojiang S. Chen
    Pages 89-111
  6. Sriram Vijayraghavan, Anthony Schwacha
    Pages 113-134
  7. Katsuhiko Kamada
    Pages 135-156
  8. Luca Pellegrini
    Pages 157-169
  9. Aishwarya Prakash, Gloria E. O. Borgstahl
    Pages 171-196
  10. Wenyue Du, Melissa E. Stauffer, Brandt F. Eichman
    Pages 197-216
  11. Matthew Hogg, Erik Johansson
    Pages 237-257
  12. Nina Y. Yao, Mike O’Donnell
    Pages 259-279
  13. Lynne M. Dieckman, Bret D. Freudenthal, M. Todd Washington
    Pages 281-299
  14. L. David Finger, John M. Atack, Susan Tsutakawa, Scott Classen, John Tainer, Jane Grasby et al.
    Pages 301-326
  15. Timothy R. L. Howes, Alan E. Tomkinson
    Pages 327-341
  16. Back Matter
    Pages 343-345

About this book

Introduction

Successful chromosome replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Inspired by recent exciting breakthroughs in protein structure determination and written by leading experts in the field, The Eukaryotic Replisome: a guide to protein structure and function takes the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosomal DNA replication, from replication origin recognition and the assembly of the pre-replicative complexes in G1 through to the final processing of Okazaki fragments at the end of S-phase. This extensively illustrated book is an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.

Keywords

DNA replication chromosome replication genome duplication protein structure replisome

Editors and affiliations

  • Stuart MacNeill
    • 1
  1. 1., School of BiologyUniversity of St AndrewsSt AndrewsUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-4572-8
  • Copyright Information Springer Science+Business Media Dordrecht 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-4571-1
  • Online ISBN 978-94-007-4572-8
  • Series Print ISSN 0306-0225
  • About this book