Systems Metabolic Engineering

  • Christoph Wittmann
  • Sang Yup Lee

Table of contents

  1. Front Matter
    Pages i-xii
  2. Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth et al.
    Pages 1-23
  3. Daniel C. Zielinski, Bernhard Ø. Palsson
    Pages 25-55
  4. Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu
    Pages 57-81
  5. Sonja Billerbeck, Sven Dietz, Gaspar Morgado, Sven Panke
    Pages 83-115
  6. Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, Sang Yup Lee
    Pages 117-149
  7. I. Emrah Nikerel, Peter J. T. Verheijen, Walter M. van Gulik, Joseph J. Heijnen
    Pages 221-270
  8. António Roldão, Il-Kwon Kim, Jens Nielsen
    Pages 271-327
  9. Tomohisa Hasunuma, Fumio Matsuda, Akihiko Kondo
    Pages 329-348
  10. Paulo A. Gameiro, Christian M. Metallo, Gregory Stephanopoulos
    Pages 349-381
  11. Back Matter
    Pages 383-387

About this book


Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production.


Integrating systems biology and biotechnology with new concepts from synthetic biology, it enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises.

This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundament to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter into this exiting field.


In Silico Design of Cell Factories Industrial Biotechnology Metabolic Engineering Systems Biology and Biotechnology

Editors and affiliations

  • Christoph Wittmann
    • 1
  • Sang Yup Lee
    • 2
  1. 1.Inst. BioverfahrenstechnikTU BraunschweigBraunschweigGermany
  2. 2.Science and Technology-KAIST, Dept. Biosystems a. BioinformaticsKorea Advanced InstituteDaejeonKorea, Republic of (South Korea)

Bibliographic information