Mortalin Biology: Life, Stress and Death

  • Sunil C. Kaul
  • Renu Wadhwa

Table of contents

  1. Front Matter
    Pages 1-1
  2. Structure and Function of Mortalin

    1. Front Matter
      Pages 1-1
    2. Custer C. Deocaris, Sunil C. Kaul, Renu Wadhwa
      Pages 21-30
    3. Wen-I Luo, James A. Cowan
      Pages 31-54
    4. Walter A. Baseler, Tara L. Croston, John M. Hollander
      Pages 55-80
  3. Mortalin in Evolution2 Deocaris

  4. Mortalin in Health and Disease

    1. Front Matter
      Pages 127-127
    2. Moran Saar, Oren Moskovich, Zvi Fishelson
      Pages 129-137
    3. Jinghua Jin, Jing Zhang, Travis J. Cook, Jake G. Hoekstra
      Pages 139-158
    4. Robin E. White, Yi-Bing Ouyang, Rona G. Giffard
      Pages 179-190
    5. Joseph P. Gabriele, Sarah E. Groleau, Ritesh P. Daya, Zdenek B. Pristupa, Ram K. Mishra
      Pages 191-207
    6. Alberto J. L. Macario, Francesco Cappello, Everly Conway de Macario
      Pages 209-221
  5. Mortalin and Cancer

    1. Front Matter
      Pages 223-223
    2. Ohad Iosefson, Abdussalam Azem
      Pages 225-244
    3. Angheliki Nomikos, Sinclair R. Dundas, Graeme I. Murray
      Pages 257-265
    4. Wen-Jing Lu, Nikki P. Lee, Renu Wadhwa, John M. Luk
      Pages 267-278
    5. Chae-Ok Yun, Renu Wadhwa
      Pages 279-291
  6. Mortalin Based Technologies

    1. Front Matter
      Pages 293-293
    2. Ran Gao, Zeenia Kaul, Tomoko Yaguchi, Renu Wadhwa
      Pages 307-322
    3. Zeenia Kaul, Tomoko Yaguchi, Renu Wadhwa, Sunil C. Kaul
      Pages 323-335
  7. Back Matter
    Pages 323-323

About this book


The phrase “Life, stress and death” connects three terms, but is there a biological basis for that? Are there molecules that are essential to/or mediate these phenomena? This contributory volume “Mortalin Biology: Life, Stress and Death” is a remarkable compilation of the research outcomes on the stress protein mortalin, a member of heat shock 70 family of proteins. The book is unique as it describes mortalin playing essential role in life, stress response and death either from cancer, when it becomes hyperactive or from neuro-degeneration, when it becomes hypoactive. The book provides up-to-date knowledge on mortalin with respect to its discovery, structure, evolutionary conservation, function and signal transduction in different organisms in a simple, but most comprehensive way, that besides offering an enjoyable and in-depth reading, prompts the reader to ask further questions to explore this protein with new ideas, approaches and experiments. Twenty-one chapters by the world leaders on the specific areas of mortalin research throw light on its multi-functionality, potentials for biotechnology, diagnostics and therapeutic values. Avenues of mortalin biology, yet unexplored, hold immense promises for future, and reading this volume provides an easy, enthusiastic and energetic head-on start.


Cancer Mortalin Neurological disease Stress Protein Therapy

Editors and affiliations

  • Sunil C. Kaul
    • 1
  • Renu Wadhwa
    • 2
  1. 1.National Institute of Advanced IndustriaTsukubaJapan
  2. 2.Science & Technology (AIST)National Insitute of Advanced IndustrialTsukubaJapan

Bibliographic information