Phosphoinositides II: The Diverse Biological Functions

  • Tamas Balla
  • Matthias Wymann
  • John D. York
Part of the Subcellular Biochemistry book series (SCBI, volume 59)

Table of contents

  1. Front Matter
    Pages 1-1
  2. Colin W. Taylor, David L. Prole
    Pages 1-34
  3. Peter J. Cullen, Jeremy G. Carlton
    Pages 65-110
  4. Samuel G. Frere, Belle Chang-Ileto, Gilbert Di Paolo
    Pages 131-175
  5. Li Zhang, Yuntao S. Mao, Paul A. Janmey, Helen L. Yin
    Pages 177-215
  6. Michael C. Weiger, Carole A. Parent
    Pages 217-254
  7. Giovanni D’Angelo, Mariella Vicinanza, Cathal Wilson, Maria Antonietta De Matteis
    Pages 255-270
  8. Carl J. Mousley, James M. Davison, Vytas A. Bankaitis
    Pages 271-287
  9. Roberta Fiume, Willem Jan Keune, Irene Faenza, Yvette Bultsma, Giulia Ramazzotti, David R. Jones et al.
    Pages 335-361
  10. Bernard Payrastre, Frédérique Gaits-Iacovoni, Philippe Sansonetti, Hélène Tronchère
    Pages 363-388
  11. Stephen B. Shears, Sindura B. Ganapathi, Nikhil A. Gokhale, Tobias M. H. Schenk, Huanchen Wang, Jeremy D. Weaver et al.
    Pages 389-412
  12. Adolfo Saiardi
    Pages 413-443
  13. Back Matter
    Pages 439-439

About this book

Introduction

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization.

The two volumes on “Phosphoinositides” provide a concise overview of the latest developments in the field of phosphoinositide hemostasis and function, and provide introductory background and extensions into unexplored territory.

Keywords

PI 3-kinase PTEN kinase phosphatase phosphoinositide

Editors and affiliations

  • Tamas Balla
    • 1
  • Matthias Wymann
    • 2
  • John D. York
    • 3
  1. 1., NICHDNational Institutes of HealthBethesdaUSA
  2. 2., Cancer- and ImmunobiologyUniversity of BaselBaselSwitzerland
  3. 3., Pharmacology and Cancer BiologyDuke University Medical CenterDurhamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-3015-1
  • Copyright Information Springer Science+Business Media B.V. 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-3014-4
  • Online ISBN 978-94-007-3015-1
  • Series Print ISSN 0306-0225
  • About this book