Stem Cells and Human Diseases

  • Rakesh Srivastava
  • Sharmila Shankar

Table of contents

  1. Front Matter
    Pages i-ix
  2. Brahma N. Singh, Sharmila Shankar, Rakesh K. Srivastava
    Pages 1-22
  3. Wojciech Maksymowicz, Joanna Wojtkiewicz, Hanna Kozłowska, Aleksandra Habich, Wlodek Lopaczynski
    Pages 23-60
  4. Brittni A. Scruggs, Xiujuan Zhang, Jeffrey M. Gimble, Bruce A. Bunnell
    Pages 61-90
  5. Yalan Xing, Willis X. Li
    Pages 91-99
  6. Peiman Hematti, Jaehyup Kim, Minoo Battiwalla
    Pages 101-115
  7. Ortiz-Sánchez Elizabeth, González-Montoya José Luis, Langley Elizabeth, García-Carrancá Alejandro
    Pages 117-148
  8. Senthil K. Pazhanisamy, Keith Syson Chan
    Pages 149-174
  9. Kern Rei Chng, Shin Chet Chuah, Edwin Cheung
    Pages 175-196
  10. Suman Kanji, Vincent J. Pompili, Hiranmoy Das
    Pages 197-216
  11. Rohit Duggal, Boris Minev, Angelo Vescovi, Aladar Szalay
    Pages 217-228
  12. Sara M. Nolte, Sheila K. Singh
    Pages 229-246
  13. Vincenzo Giambra, Christopher R. Jenkins
    Pages 267-306
  14. Saleh Heneidi, Gregorio Chazenbalk
    Pages 323-351
  15. Kim Hei-Man Chow, Paul Kwong-Hang Tam, Elly Sau-Wai Ngan
    Pages 353-386
  16. Grzegorz Wicher, Karin Holmqvist, Karin Forsberg-Nilsson
    Pages 387-418
  17. Sara G. M. Piccirillo
    Pages 419-431
  18. Rajneesh Pathania, Vadivel Ganapathy, Muthusamy Thangaraju
    Pages 433-450

About this book

Introduction

There have been major advances in understanding the behavior of stem cells and their roles in tissue regeneration, homeostasis and therapy.  Cancer stem cell hypothesis opened a new opportunity for treating and preventing cancers by targeting cancer stem cells or cancer initiating cells.  An increased understanding of stem cell behavior and biology along with rapid advancement of high throughput screening has led to the discovery and development of novel drugs that control stem cell self-renewal and differentiation.  In near future, these molecules will be very useful for treating and preventing several human diseases. 

While progress on the clinical front has been slower than desired, the use of stem cells for tissue regeneration and disease management has great potential in human health.

The first decade of the 21st century has brought with it significant progress in our understanding of stem cell or progenitor cells and their role in tissue regeneration and management of human diseases including cancer, neurodegenerative disorders, and heart diseases.  This book covers the current state-of-the-art knowledge on the role of stem cells in tissue regeneration, homeostasis and disease management.

Features:

  • Coverage of the biology of stem cell and their role in tissue regeneration and organogenesis.
  • Mechanism-based strategies for stem cell self-renewal and differentiation.
  • Role of cancer stem cells or tumor initiating cells in cancer initiation, progression, relapse and drug resistance.
  • Use of stem cells in treating several human diseases, such as Alzheimer’s disease, Parkinson’s disease, cancer and diabetes.

Keywords

Cancer Stem Cells Drug Resistance Physiology and Metabolisms Stem Cells microRNA

Editors and affiliations

  • Rakesh Srivastava
    • 1
  • Sharmila Shankar
    • 2
  1. 1., Pharmacology and ToxicologyUniversity of Kansas Medical CenterKansas CityUSA
  2. 2., Pathology and Laboratory MedicineUniversity of Kansas Medical CenterKansas CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-2801-1
  • Copyright Information Springer Science+Business Media B.V. 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-2800-4
  • Online ISBN 978-94-007-2801-1
  • About this book