Cancer Systems Biology, Bioinformatics and Medicine

Research and Clinical Applications

  • Alfredo Cesario
  • Frederick Marcus

Table of contents

  1. Front Matter
    Pages 1-1
  2. Introduction and Background

    1. Front Matter
      Pages 1-1
    2. Frederick B. Marcus, Alfredo Cesario
      Pages 3-27
    3. Antonio Llombart-Bosch, Ulrik Ringborg, Sergio Rutella, Julio E. Celis
      Pages 29-93
  3. Laboratory, Clinical, Data and Educational Resources

    1. Front Matter
      Pages 95-95
    2. Bodo M. H. Lange, Michal R. Schweiger, Hans Lehrach
      Pages 97-126
    3. Anna Tramontano, Alfonso Valencia
      Pages 165-181
  4. Bioinformatics and Systems Biology Analysis

    1. Front Matter
      Pages 183-183
    2. Julio Vera, Olaf Wolkenhauer
      Pages 185-212
    3. Edda Klipp, Falko Krause
      Pages 213-243
    4. Charles Auffray, Trey Ideker, David J. Galas, Leroy Hood
      Pages 245-266
    5. Jan G. Hengstler, Mathias Gehrmann, Stefan Höhme, Dirk Drasdo, Joanna D. Stewart, Marcus Schmidt
      Pages 297-307
  5. Diagnosis, Clinical and Treatment Applications

    1. Front Matter
      Pages 327-327
    2. Christopher Snell, David Orrell, Eric Fernandez, Christophe Chassagnole, David Fell
      Pages 367-380
    3. Francis Lévi, Atilla Altinok, Albert Goldbeter
      Pages 381-407
    4. Sergio Iadevaia, Adel B. Tabchy, Prahlad T. Ram, Gordon B. Mills
      Pages 409-428
    5. Hiroaki Kitano
      Pages 429-446
  6. Perspectives and Conclusions

    1. Front Matter
      Pages 447-447
    2. Toru Yao, Frederick B. Marcus
      Pages 449-469
    3. Alfredo Cesario, Frederick B. Marcus
      Pages 471-477
  7. Back Matter
    Pages 467-467

About this book


This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis, by world-class scientists and doctors, of laboratory, computational, and clinical methods, thereby establishing the foundations for major advances not possible with current methods.  Specifically, the book: 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches, and the clinical background of cancer in a systems context; 2) Summarizes the laboratory, clinical, data systems analysis and bioinformatics tools, along with infrastructure and resources required; 3) Demonstrates the application of these tools to cancer research; 4) Extends these tools and methods to clinical diagnosis, drug development and treatment applications; and 5) Finishes by exploring longer term perspectives and providing conclusions. This book reviews the state-of-the-art, and goes beyond into new applications. It is written and highly referenced as a textbook and practical guide aimed at students, academics, doctors, clinicians, industrialists and managers in cancer research and therapeutic applications. Ideally, it will set the stage for integration of available knowledge to optimize communication between basic and clinical researchers involved in the ultimate fight against cancer, whatever the field of specific interest, whatever the area of activity within translational research.


Bioinformatics Cancer Systems Biology Systems Medicine

Editors and affiliations

  • Alfredo Cesario
    • 1
  • Frederick Marcus
    • 2
  1. 1.RomeItaly
  2. 2.RixensartBelgium

Bibliographic information