Cell Death in Mammalian Ovary

  • Gerardo H. Vázquez-Nin
  • María Luisa Escobar
  • M. De Felici
  • Olga Margarita Echeverría
  • Francesca Gioia Klinger

Table of contents

  1. Front Matter
    Pages i-vi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. María Luisa Escobar, Gerardo H. Vázquez-Nin, Olga M. Echeverría
      Pages 3-24
    3. Gerardo H. Vázquez-Nin, María Luisa Escobar, Olga M. Echeverría
      Pages 25-48
    4. Gerardo H. Vázquez-Nin, María Luisa Escobar, Olga M. Echeverría, Massimo De Felici
      Pages 49-59
  3. General Aspects of Cell Death

    1. Front Matter
      Pages 61-61
    2. María Luisa Escobar, Gerardo H. Vázquez-Nin, Olga M. Echeverría
      Pages 63-80
    3. María Luisa Escobar, Gerardo H. Vázquez-Nin, Olga M. Echeverría
      Pages 81-102
    4. María Luisa Escobar, Gerardo H. Vázquez-Nin, Olga M. Echeverría
      Pages 103-110
    5. Gerardo H. Vázquez-Nin, María Luisa Escobar, Olga M. Echeverría
      Pages 111-121
  4. Process of Cell Death Embryonic Ovary

    1. Front Matter
      Pages 123-123
    2. Francesca Gioia Klinger, Massimo De Felici
      Pages 125-142
    3. Massimo De Felici, Francesca Gioia Klinger
      Pages 143-163
    4. María Luisa Escobar, Gerardo H. Vázquez-Nin, Olga M. Echeverría
      Pages 165-170
  5. Process of Cell Death Prepubertal Ovary

    1. Front Matter
      Pages 171-171
    2. Gerardo H. Vázquez-Nin, María Luisa Escobar, Olga M. Echeverría
      Pages 173-184
    3. María Luisa Escobar, Gerardo H. Vázquez-Nin, Olga M. Echeverría
      Pages 185-200
  6. Process of Cell Death Adult Ovary

    1. Front Matter
      Pages 201-201
    2. Gerardo H. Vázquez-Nin, María Luisa Escobar, Olga M. Echeverría
      Pages 203-219
    3. Gerardo H. Vázquez-Nin, María Luisa Escobar, Olga M. Echeverría
      Pages 221-232

About this book

Introduction

The ovary is a suitable organ for studying the processes of cell death. Cell death was first described in the rabbit ovary (Graaffian follicles), the phenomenon being called ‘chromatolysis’. To date, it is recognized that various forms of cell death (programmed cell death, apoptosis and autophagy) are essential components of ovarian development and function. Programmed cell death is responsable for the ovarian endowment of primordial follicles around birth; in the prepuberal and adult period, apoptosis is a basic mechanism by which oocytes are eliminated by cancer therapies and environmental toxicants; in the ovarian cycle, follicular atresia and luteal regression involve follicular cell apoptosis. Finally, abnormalities in cell death processes may lead to ovarian disease such as cancer and chemoresistance. In this book, after an introductory description of various forms of cell death and of the ovary development and function in mammals, the processes of cell death in ovarian somatic cells and oocytes are described at cytological, physiological and molecular levels and analyzed in the embryonic, prepuberal and adult ovary. A complex array of molecular pathways triggered by extrinsic and intrinsic signals able tor induce or suppress cell death in the same cell, according to cell type and ovary developmental stage, emerges. Physiological interactions with the axis hypothalamus-hypophysis as well as ovarian internal functional signal are also critically reviewed to explain the abortive development of follicles before the beginning of the ovarian cycle. The book conveys information useful to the updating of biologists and physicians who are interested to the ovary biology and functions. Hopefully it should provide also clues for stimulating novel experiments in the study of cell death in the mammalian ovary still at an early stage.

Keywords

Apoptosis Autophagy Oocyte Ovary Programmed Cell Death

Authors and affiliations

  • Gerardo H. Vázquez-Nin
    • 1
  • María Luisa Escobar
    • 2
  • M. De Felici
    • 3
  • Olga Margarita Echeverría
    • 4
  • Francesca Gioia Klinger
    • 5
  1. 1.National Autonomous University of M, Department of Cell BiologyFaculty of SciencesMexico, D.F.Mexico
  2. 2.National Autonomous Univ. of Mexico UNAM, Department of Cell BiologyFaculty of SciencesMexico, D.F.Mexico
  3. 3.University of Rome Tor Vergata, Department of Public Health and Cell BioSection of Histology and EmbryologyRomeItaly
  4. 4.National Autonomous University of Mexico, Department of Cell BiologyFaculty of SciencesMexico, D.F.Mexico
  5. 5.University of Rome Tor Vergata, Department of Public Health and Cell BioSection of Histology and EmbryologyRomeItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-1134-1
  • Copyright Information Springer Science+Business Media B.V. 2011
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-1133-4
  • Online ISBN 978-94-007-1134-1
  • About this book