Portal Hypertension in the 21st Century

The proceedings of a symposium sponsored by Axcan Pharma Inc. and NicOx S.A., held in Montrél, Canada, April 2–4, 2004

  • R. J. Groszmann
  • J. Bosch
Conference proceedings

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introductory lectures

  3. Mechanism of disease progression

    1. Front Matter
      Pages 25-25
    2. Scott L. Friedman
      Pages 27-35
  4. Pathophysiology: increased resistance and increased blood flow

    1. Front Matter
      Pages 55-55
    2. Yasuko Iwakiri, Roberto J. Groszmann
      Pages 57-67
    3. Mauricio R. Loureiro-Silva, Roberto J. Groszmann
      Pages 81-88
    4. Juan Carlos García-Pagán
      Pages 89-96
    5. Wladimiro Jimënez, Josefa Ros
      Pages 97-101
  5. Mini-symposium: Possibilities of manipulating NO biosynthesis in the treatment of portal hypertension

    1. Front Matter
      Pages 103-103
    2. Stefano Fiorucci, Elisabetta Antonelli, Antonio Morelli
      Pages 105-110
    3. June Sung Lee, Vijay Shah
      Pages 127-131
  6. Introduction to variceal bleeding

  7. Therapeutic tools

    1. Front Matter
      Pages 173-173
    2. Agustín Albillos
      Pages 175-184
    3. Gregory J. Monkewich, Norman E. Marcon
      Pages 185-207
    4. Ziad Hassoun, Gilles Pomier-Layrargues
      Pages 209-217
  8. Present therapy

    1. Front Matter
      Pages 219-219
    2. Didier Lebrec
      Pages 221-226
    3. Michael Schepke, Tilman Sauerbruch
      Pages 227-231
    4. Roberto De Franchis
      Pages 241-249
  9. Problems in treatment

    1. Front Matter
      Pages 269-269
    2. Carlo Merkel, Massimo Bolognesi, Angelo Gatta
      Pages 271-276
    3. S.K. Sarin
      Pages 277-300
    4. Thomas D. Boyer
      Pages 301-307
    5. Julio D. Vorobioff, Juan G. Abraldes, Roberto J. Groszmann
      Pages 309-322
    6. Ulrich Thalheimer, Dimitrios Samonakis, Christos Triantos, David Patch, Andrew K. Burroughs
      Pages 323-336
    7. Càndid Villanueva, Carles Aracil, Joaquim Balanzó
      Pages 337-348
    8. Juan Turnes, Juan Carlos Garcia-Pagan, Jaime Bosch
      Pages 349-360
  10. Back Matter
    Pages 361-370

About these proceedings


Portal hypertension is the most important complication of a great variety of both acute and chronic liver diseases. Nevertheless, hepatic cirrhosis is the most frequent cause of portal hypertension. Gastrointestinal bleeding due to rupture of oesophageal varices is, without doubt, the most severe complication of portal hypertension. At present, great advances are being made in the pathophysiology and in the development of new therapeutic tools for controlling and preventing this severe clinical event.

This book contains the papers presented and discussed during the Symposium on 'Portal Hypertension in the 21st Century', held in Montréal, Canada, in April 2004, and sponsored by Axcan Pharma Inc. and NicOx S.A. There are eight sections covering basic mechanisms, new drugs, prevention and current treatment of variceal bleeding, prevention of recurrent bleeding and hepatic hemodynamic monitoring.

An international faculty of authors have contributed chapters at an outstanding scientific level which will be vital reading for scientists and clinicians alike.


TIPS bile bile acid bile duct bilirubin cirrhosis dynamics gallbladder gallstone koffie liver liver disease portal hypertension portosystemic shunt transjugular intrahepatic portosystemic shunt

Editors and affiliations

  • R. J. Groszmann
    • 1
  • J. Bosch
    • 2
  1. 1.Yale University School of MedicineNew HavenUSA
  2. 2.Hepatic Hemodynamic Laboratory Liver Unit, Hospital ClinicUniversity of BarcelonaSpain

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers and Axcan Pharma Inc. 2004
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-3774-7
  • Online ISBN 978-94-007-1042-9
  • Buy this book on publisher's site