Tumors of the Central Nervous System, Volume 2

Gliomas: Glioblastoma (Part 2)

  • M.A. Hayat

Part of the Tumors of the Central Nervous System book series (TCNS, volume 2)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. M.A. Hayat
    Pages 1-7
  3. Biomarkers and Diagnosis

    1. Front Matter
      Pages 9-9
    2. Michel Wager, Lucie Karayan-Tapon, Christian-Jacques Larsen
      Pages 11-24
    3. Lonneke A.M. Gravendeel, Pim J. French
      Pages 25-29
    4. Haruhiko Sugimura, Hidetaka Yamada, Shinji Kageyama, Yasuhiro Yamamura, Naoki Yokota, Hiroki Mori et al.
      Pages 31-38
    5. Soufiane El Hallani, Ilham Ratbi
      Pages 39-45
    6. Yukihiko Sonoda, Ichiyo Shibahara, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga
      Pages 47-52
    7. Zachary J. Reitman, Hai Yan
      Pages 53-62
    8. Francisca M. Santandreu, Jordi Oliver, Pilar Roca
      Pages 63-72
    9. Giulio Metro, Alessandra Fabi
      Pages 73-79
    10. Zhong-Ping Chen, Yin-Sheng Chen
      Pages 93-101
    11. Sumei Wang, Harish Poptani, Elias R. Melhem, Sungheon Kim
      Pages 113-121
    12. Adam N. Mamelak, David Hockaday
      Pages 123-130
    13. Rebecca Senetta, Paola Cassoni
      Pages 143-149
  4. Therapy

    1. Front Matter
      Pages 151-151

About this book

Introduction

Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.

Keywords

Chemotherapy Diagnosis of brain tumors Glioblastoma multiforme Radiotherapy Treatment of brain tumors

Editors and affiliations

  • M.A. Hayat
    • 1
  1. 1., Kean UniversityRoom 213, Library buildingUnionUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-0618-7
  • Copyright Information Springer Science+Business Media B.V. 2011
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine
  • Print ISBN 978-94-007-0617-0
  • Online ISBN 978-94-007-0618-7
  • About this book