Tumors of the Central Nervous System, Volume 2

Gliomas: Glioblastoma (Part 2)

  • M.A. Hayat

Part of the Tumors of the Central Nervous System book series (TCNS, volume 2)

Table of contents

  1. Front Matter
    Pages i-xxi
  2. M.A. Hayat
    Pages 1-7
  3. Biomarkers and Diagnosis

    1. Front Matter
      Pages 9-9
    2. Michel Wager, Lucie Karayan-Tapon, Christian-Jacques Larsen
      Pages 11-24
    3. Lonneke A.M. Gravendeel, Pim J. French
      Pages 25-29
    4. Haruhiko Sugimura, Hidetaka Yamada, Shinji Kageyama, Yasuhiro Yamamura, Naoki Yokota, Hiroki Mori et al.
      Pages 31-38
    5. Soufiane El Hallani, Ilham Ratbi
      Pages 39-45
    6. Yukihiko Sonoda, Ichiyo Shibahara, Ryuta Saito, Toshihiro Kumabe, Teiji Tominaga
      Pages 47-52
    7. Zachary J. Reitman, Hai Yan
      Pages 53-62
    8. Francisca M. Santandreu, Jordi Oliver, Pilar Roca
      Pages 63-72
    9. Giulio Metro, Alessandra Fabi
      Pages 73-79
    10. Zhong-Ping Chen, Yin-Sheng Chen
      Pages 93-101
    11. Sumei Wang, Harish Poptani, Elias R. Melhem, Sungheon Kim
      Pages 113-121
    12. Adam N. Mamelak, David Hockaday
      Pages 123-130
    13. Rebecca Senetta, Paola Cassoni
      Pages 143-149
  4. Therapy

    1. Front Matter
      Pages 151-151
    2. Johan Pallud, Emmanuel Mandonnet
      Pages 163-172
    3. Debraj Mukherjee, Alfredo Quinones-Hinojosa
      Pages 173-179
    4. Linda Coate, Warren Mason
      Pages 207-214
    5. Tetsuya Yamamoto, Kei Nakai, Hiroaki Kumada
      Pages 229-239
    6. Bozena Kaminska, Magdalena Tyburczy, Konrad Gabrusiewicz, Malgorzata Sielska
      Pages 241-253
    7. Florence Lefranc, Robert Kiss
      Pages 261-267
    8. Atsushi Natsume, Masasuke Ohno, Kanako Yuki, Kazuya Motomura, Toshihiko Wakabayashi
      Pages 269-276
    9. Aleksandra Ellert-Miklaszewska, Iwona Ciechomska, Bozena Kaminska
      Pages 277-287
    10. Benedikte Hasselbalch, Ulrik Lassen, Hans Skovgaard Poulsen
      Pages 289-299
    11. Timo Liimatainen, Olli Gröhn, Kimmo Lehtimäki
      Pages 301-311
    12. Hilko Ardon, Steven De Vleeschouwer, Frank Van Calenbergh, Stefaan W. Van Gool
      Pages 313-333
    13. Thomas Wirth, Haritha Samaranayake, Seppo Ylä-Herttuala
      Pages 335-347
    14. David Fortin
      Pages 349-359
    15. Florence Laigle-Donadey, Jean-Yves Delattre
      Pages 371-377
  5. Prognosis

    1. Front Matter
      Pages 385-385
    2. Marco Antonio Lima
      Pages 387-395
    3. Anja Smits, Anette Storstein
      Pages 397-406
    4. Dave F. Clarke, Timothy M. George
      Pages 425-434
  6. Back Matter
    Pages 435-458

About this book


Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.


Chemotherapy Diagnosis of brain tumors Glioblastoma multiforme Radiotherapy Treatment of brain tumors

Editors and affiliations

  • M.A. Hayat
    • 1
  1. 1., Kean UniversityRoom 213, Library buildingUnionUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2011
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-94-007-0617-0
  • Online ISBN 978-94-007-0618-7
  • Buy this book on publisher's site