Advances in Nuclear Architecture

  • Niall M. Adams
  • Paul S. Freemont

Table of contents

  1. Front Matter
    Pages i-vii
  2. Kendra L. Cann, Sui Huang, Graham Dellaire
    Pages 1-58
  3. Philip P. Umande, David A. Stephens
    Pages 59-85
  4. Daniel Hübschmann, Nikolaus Kepper, Christoph Cremer, Gregor Kreth
    Pages 87-129
  5. Siwei Yang, Doris Illner, Kathrin Teller, Irina Solovei, Roel van Driel, Boris Joffe et al.
    Pages 131-147
  6. Richard A. Russell, Niall M. Adams, David Stephens, Elizabeth Batty, Kirsten Jensen, Paul S. Freemont
    Pages 173-187
  7. Dean A. Jackson
    Pages 189-205
  8. Back Matter
    Pages 207-210

About this book


This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.

Editors and affiliations

  • Niall M. Adams
    • 1
  • Paul S. Freemont
    • 2
  1. 1.Department of MathematicsImperial CollegeLondonUnited Kingdom
  2. 2.Div. Molecular BiosciencesImperial College LondonLondonUnited Kingdom

Bibliographic information