Mechanosensitivity and Mechanotransduction

  • Andre Kamkin
  • Irina Kiseleva

Part of the Mechanosensitivity in Cells and Tissues book series (MECT, volume 4)

Table of contents

  1. Front Matter
    Pages i-xxiv
  2. The Role of Cytoskeleton in Mechanosensitivity and Mechanotransduction

    1. Front Matter
      Pages 1-1
    2. Kay-Pong Yip, Lavanya Balasubramanian, James S. K. Sham
      Pages 3-24
    3. Tianzhi Luo, Douglas N. Robinson
      Pages 25-65
    4. Qiang Fu, Yiping Zhang, Yajuan Xu, Yourui Li, Ling Guo, Minfeng Shao
      Pages 67-76
  3. Molecular Mechanisms of Mechanotransduction and Ion Channels Modulation

    1. Front Matter
      Pages 107-107
    2. Victor Kazanski, Andre Kamkin, Ekaterina Makarenko, Natalia Lysenko, Natalia Lapina, Irina Kiseleva
      Pages 109-140
  4. Mechanosensitivity and Mechanotransduction in Vascular Cells

  5. Mechanotransduction in the Lung

    1. Front Matter
      Pages 237-237
    2. James C. Parker, Mary I. Townsley
      Pages 239-254
  6. Mechanosensing and Mechanotransduction in Bone and Joint Tissues

    1. Front Matter
      Pages 275-275
    2. Suzanne R.L. Young, Fredrick M. Pavalko
      Pages 277-296
    3. Christelle Sanchez, Marianne Mathy-Hartert, Yves Henrotin
      Pages 297-313
  7. Mechanotransduction of Sensor System

    1. Front Matter
      Pages 315-315
    2. Surya M. Nauli, Hanan S. Haymour, Wissam A. Aboualaiwi, Shao T. Lo, Andromeda M. Nauli
      Pages 317-350
  8. Mechanosensitivity and Mechanotransduction in Blood Cells

  9. Back Matter
    Pages 369-371

About this book


This book presents the latest findings in the field of research of mechanosensitivity and
mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction
of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It  contains a detailed description of several  stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of  nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii  cations via intracellular cytoskeletal reorganization and
extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume  highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes.

This book is a unique collection of reviews outlining current knowledge and future developments
in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of
studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. 

This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.


Cytoskeleton Mechanically gated channels Mechanosensitivity Mechanotransduction Stretch-induced signaling cascades

Editors and affiliations

  • Andre Kamkin
    • 1
  • Irina Kiseleva
    • 2
  1. 1.Chemical DepartmentMoscow State UniversityMoscowRussian Federation
  2. 2., Department of Fundamental and Applied PhRussian State Medical UniversityMoscowRussian Federation

Bibliographic information