From Molecular to Modular Tumor Therapy

Tumors are Reconstructible Communicatively Evolving Systems

  • Albrecht Reichle

Part of the The Tumor Microenvironment book series (TTME, volume 3)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Therapy-Derived Systems Biology: A Pragmatic Communication Theory

  3. Tumors Share Common Processes During Tumor Evolution: Communicative Aspects of a Situation’s Interpretation for Creating Systems-Directed Therapies

  4. Systems-Relevant Molecular and Cellular Targets: Implementation of Modular ‘Knowledge’

    1. Front Matter
      Pages 159-159
    2. Ilse M. E. Beck, Guy Haegeman, Karolien De Bosscher
      Pages 191-242
  5. Tumors are Evolvable Modular and Rationalized Systems: From Molecular to Modular Tumor Therapy

    1. Front Matter
      Pages 263-263
    2. Albrecht Reichle, Thomas Vogt
      Pages 265-285
    3. Albrecht Reichle, Gerhard C. Hildebrand
      Pages 305-309
  6. Biomodulatory Therapy Approaches in Metastatic Cancer

    1. Front Matter
      Pages 311-311
    2. Ulrika Smedh, Annika Gustafsson, Hans Axelsson, Christian Cahlin, Christina Lönnroth, Kent Lundholm
      Pages 313-340
    3. Albrecht Reichle, Frank Klebl, Klaus Bross, Frank Kullmann, Peter Wild, Anna Berand et al.
      Pages 341-352
    4. Bernhard Walter, Irmela Schrettenbrunner, Martin Vogelhuber, Jochen Grassinger, Klaus Bross, Jochen Wilke et al.
      Pages 353-366
    5. Bernhard Walter, Sebastian Rogenhofer, Martin Vogelhuber, Jochen Wilke, Anna Berand, Walter Ferdinand Wieland et al.
      Pages 367-377
    6. Albrecht Reichle, Martin Vogelhuber, Anna Berand, Reinhard Andreesen, Irene Fackler-Schwalbe, Annemarie Rübel et al.
      Pages 379-382
  7. Criteria for Checking Systems Behavior and Creating Predictions: Systems-Associated Biomarkers and Molecular Imaging

    1. Front Matter
      Pages 383-383
    2. Verena Paulitschke, Rainer Kunstfeld, Christopher Gerner
      Pages 405-431
    3. Stefanie Meyer, Thomas Vogt, Michael Landthaler, Anna Berand, Albrecht Reichle, Frauke Bataille et al.
      Pages 433-465
  8. Pharmacological Considerations on Systems Biological Therapy Approaches

    1. Front Matter
      Pages 467-467
  9. Tumors’ Systems Biology: Implications for Personalized Therapy

    1. Front Matter
      Pages 505-505
    2. Albrecht Reichle, Thomas Vogt, Gerhard C. Hildebrandt
      Pages 507-533
  10. Summary

    1. Front Matter
      Pages 535-535
    2. Albrecht Reichle, Gerhard C. Hildebrandt
      Pages 537-544
    3. Albrecht Reichle, Gerhard C. Hildebrandt
      Pages 545-556
  11. Back Matter
    Pages 557-566

About this book


The traditional problem of the poor presentability as well as diagnostic and therapeutic practicability of individual patient care is still unresolved. The present book aims at leading the reader (cancer researchers, pharmacologists, biologists) away―in a scientifically accessible manner―from the daily conflicts between theory and practice and between the generalized and individual tumor patient, so that more personalized diagnostic and therapeutic strategies can be developed for controlling metastatic tumor disease: • First, recording the systems concept of tumor biology based on rather different sciences (biochemistry, cell biology, and medical oncology) including their potential contribution to communication, • then, giving reductionistically derived systems features an internal communicative context (formal-pragmatic communication theory), and • finally, binding the systems features to (tumor-immanent) evolutionary processes (modularity of biochemical and cellular processes, rationalization of biologic functions).


Carcinom Communication theory (integration of communication) Evolution, modularity Holism-reductionism Tumor models Tumor-associated inflammation regulation

Editors and affiliations

  • Albrecht Reichle
    • 1
  1. 1., Department of Hematology and OncologyUniversity Hospital RegensburgRegensburgGermany

Bibliographic information