Microbial Biochemistry

Second Edition

  • G.N. Cohen

Table of contents

  1. Front Matter
    Pages i-xxviii
  2. G. N. Cohen
    Pages 1-10
  3. G. N. Cohen
    Pages 23-49
  4. G. N. Cohen
    Pages 51-62
  5. G. N. Cohen
    Pages 115-125
  6. G. N. Cohen
    Pages 127-132
  7. G. N. Cohen
    Pages 133-137
  8. G. N. Cohen
    Pages 139-161
  9. G. N. Cohen
    Pages 163-177
  10. G. N. Cohen
    Pages 179-187
  11. G. N. Cohen
    Pages 189-200
  12. G. N. Cohen
    Pages 201-207
  13. G. N. Cohen
    Pages 209-215
  14. G. N. Cohen
    Pages 217-222
  15. G. N. Cohen
    Pages 233-239
  16. G. N. Cohen
    Pages 241-244
  17. G. N. Cohen
    Pages 245-250
  18. G. N. Cohen
    Pages 363-371
  19. G. N. Cohen
    Pages 409-430
  20. G. N. Cohen
    Pages 431-442
  21. G. N. Cohen
    Pages 513-524
  22. G. N. Cohen
    Pages 525-544
  23. Back Matter
    Pages 545-557

About this book


Microbial physiology, biochemistry, and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle. The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.


biosynthetic pathways permeability regulation,archaea

Authors and affiliations

  • G.N. Cohen
    • 1
  1. 1.Institut PasteurParisFrance

Bibliographic information