Actin-based Motility

Cellular, Molecular and Physical Aspects

  • Marie-France Carlier

Table of contents

  1. Front Matter
    Pages i-xii
  2. Cellular Aspects

    1. Front Matter
      Pages 1-1
    2. Shiro Suetsugu, Tadaomi Takenawa
      Pages 35-57
    3. Andrea Disanza, Emanuela Frittoli, Chiara Giuliani, Francesca Milanesi, Andrea Palamidessi, Flavia Troglio et al.
      Pages 59-84
    4. Marko Kaksonen
      Pages 85-101
    5. Viveka Mayya, Michael L. Dustin
      Pages 103-124
    6. Matthew Oser, Robert Eddy, John Condeelis
      Pages 125-164
    7. Minna Roh-Johnson, Jessica Sullivan-Brown, Bob Goldstein
      Pages 187-209
  3. Molecular Aspects

    1. Front Matter
      Pages 211-211
    2. Pekka Lappalainen, Maarit Makkonen, Hongxia Zhao
      Pages 213-235
    3. David R. Kovar, Andrew J. Bestul, Yujie Li, Bonnie J. Scott
      Pages 279-316
    4. Emmanuèle Helfer
      Pages 317-333
  4. Physical Aspects

    1. Front Matter
      Pages 357-357
    2. Ovijit Chaudhuri, Daniel A. Fletcher
      Pages 359-379
    3. Anders E. Carlsson, Alex Mogilner
      Pages 381-412
  5. Back Matter
    Pages 433-435

About this book


This book presents the cellular, molecular and physical aspects of force and movement by the self-assembly of actin, one of the most abundant proteins found in cells, into cytoskeletal filaments. « Actin-based motile processes » are responsible for a large variety of motile activities such as chemotactic locomotion, embryonic and metastatic cell migration, wound healing, eukaryotic cytokinesis and bacterial plasmid segregation, endocytic and phagocytic activities, as well as morphogenetic processes including, axis patterning in early embryos, axonal growth in brain development, and the immune response and synaptic plasticity processes at the origin of learning and memory. The book describes how the recently undertaken multidisciplinary and multiscale approaches have explored the molecular and physical mechanisms at the origin of force and movement produced by actin self-assembly. The chosen topics show how advances have been made in the field of cell motility due to the progress in live cell imaging, light microscopy, improved resolution in the structure of large protein assemblies, the biochemical analysis and mathematical modeling of actin assembly dynamics and the development of nanotechnologies enabling us to measure forces in the range of pico- to nano-newtons produced by actin assemblies.


cell division cellular processes dynamics imaging migration protein proteins regulation

Editors and affiliations

  • Marie-France Carlier
    • 1
  1. 1., Laboratory of Structural Enzymology andCNRSGif-sur-Yvette CedexFrance

Bibliographic information