Table of contents

  1. Front Matter
    Pages i-xvii
  2. Part I Structure and Properties of Endotoxins

    1. Front Matter
      Pages 1-1
    2. Xiaoyuan Wang, Peter J. Quinn
      Pages 3-25
    3. Xiaoyuan Wang, Chan Zhang, Feng Shi, Xiaoqing Hu
      Pages 27-51
    4. K. Brandenburg, A.B. Schromm, T. Gutsmann
      Pages 53-67
    5. Alba Silipo, Antonio Molinaro
      Pages 69-99
    6. Susan M. Richards, Kristi L. Strandberg, John S. Gunn
      Pages 101-122
    7. Lei Wang, Quan Wang, Peter R. Reeves
      Pages 123-152
    8. Anne F. McGettrick, Luke A.J. O’Neill
      Pages 153-171
  3. Infection, Treatment and Immunity

    1. Front Matter
      Pages 185-185
    2. Samuel M. Moskowitz, Robert K. Ernst
      Pages 241-253
    3. Sunil A. David, Diptesh Sil
      Pages 255-283
    4. Christopher B. Fox, Martin Friede, Steven G. Reed, Gregory C. Ireton
      Pages 303-321
    5. Jean-Sebastien Rachoin, Christa A. Schorr, R. Phillip Dellinger
      Pages 323-338
    6. Russell W. Carlson, L. Scott Forsberg, Elmar L. Kannenberg
      Pages 339-386
    7. G. Erbs, A. Molinaro, J.M. Dow, M.-A. Newman
      Pages 387-403

About this book

Introduction

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death. This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases. The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.

Keywords

Antigen Sepsis bacteria infection infectious vaccine

Editors and affiliations

  • Xiaoyuan Wang
    • 1
  • Peter J. Quinn
    • 2
  1. 1.Dept. BiochemistryJiangnan UniversityWuxi, JiangsuChina, People's Republic
  2. 2.European Southern Observatory (ESO)GarchingGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-90-481-9078-2
  • Copyright Information Springer Science+Business Media B.V. 2010
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-90-481-9077-5
  • Online ISBN 978-90-481-9078-2
  • Series Print ISSN 0306-0225
  • About this book