© 2010

CCN Proteins in Health and Disease

An Overview of the Fifth International Workshop on the CCN Family of Genes

  • Annick Perbal
  • Masaharu Takigawa
  • Bernard Perbal

Table of contents

  1. Front Matter
    Pages i-xiii
  2. A. E. Irvine, B. Perbal, H. Yeger
    Pages 5-13
  3. Kenneth P. Holbourn, Bernard Perbal, K. Ravi Acharya
    Pages 15-40
  4. Satoshi Kubota, Yoshiki Mukudai, Harumi Kawaki, Seiji Kondo, Takanori Eguchi, Kumi Sumiyoshi et al.
    Pages 41-55
  5. Lan Wei, Frank McKeon, Joshua W. Russo, Joan Lemire, John Castellot
    Pages 77-95
  6. Masaharu Takigawa, Harumi Kawaki, Satoshi Kubota, Karen M. Lyons, Bernard Perbal
    Pages 105-109
  7. Ken-Ichi Katsube
    Pages 111-119
  8. Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain
    Pages 121-132
  9. Taihao Quan, Sharon Shin, Zhaoping Qin, Gary J. Fisher
    Pages 133-140
  10. Weihan Wang, Cynthia Jose, Nicholas Kenney, Bethanie Morrison, Mary Lou Cutler
    Pages 141-162
  11. Bruce. L. Riser, Feridoon Najmabadi, Bernard Perbal, Jo Ann Rambow, Melisa L. Riser, Ernest Sukowski et al.
    Pages 163-181
  12. Viviana Vallacchi, Maria Daniotti, Annamaria De Filippo, Licia Rivoltini, Bernard Perbal, Monica Rodolfo
    Pages 205-211
  13. Lynn McCallum, Alexandra E Irvine
    Pages 213-221
  14. Bernard Perbal, Noureddine Lazar, Diana Zambelli, Monia Zuntini, Massimo Serra, Jose Antonio Lopez-Guerrero et al.
    Pages 223-243
  15. Takanori Eguchi, Satoshi Kubota, Kazumi Kawata, Yoshiki Mukudai, Junji Uehara, Toshihiro Ohgawara et al.
    Pages 255-264

About this book


The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors.

The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types.

The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information.

The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology.

All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions.

In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes.

Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.


gene expression genes migration primary structure proteins regulation tissue transcription

Editors and affiliations

  • Annick Perbal
    • 1
  • Masaharu Takigawa
    • 2
  • Bernard Perbal
    • 3
  1. 1.Ann ArborUSA
  2. 2.OkayamaJapan
  3. 3.Palais du Grand LargeInternational CCN SocietySaint-MaloFrance

Bibliographic information