Genome Stability and Human Diseases

  • Heinz-Peter Nasheuer

Part of the Subcellular Biochemistry book series (SCBI, volume 50)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. David Miguel Susano Pinto, Andrew Flaus
    Pages 55-78
  3. Helmut Pospiech, Frank Grosse, Francesca M. Pisani
    Pages 79-104
  4. Miiko Sokka, Sinikka Parkkinen, Helmut Pospiech, Juhani E. Syväoja
    Pages 119-141
  5. Sandra Broderick, Kristina Rehmet, Claire Concannon, Heinz-Peter Nasheuer
    Pages 143-163
  6. Emmanuele Crespan, Alessandra Amoroso, Giovanni Maga
    Pages 165-188
  7. Séverine Cruet-Hennequart, Kathleen Gallagher, Anna M. Sokòl, Sangamitra Villalan, Áine M. Prendergast, Michael P. Carty
    Pages 189-209
  8. William C. Copeland
    Pages 211-222
  9. Macdara Glynn, Agnieszka Kaczmarczyk, Lisa Prendergast, Nadine Quinn, Kevin F. Sullivan
    Pages 223-249
  10. Michael R. Lieber, Jiafeng Gu, Haihui Lu, Noriko Shimazaki, Albert G. Tsai
    Pages 279-296
  11. Chiara Mondello, A. Ivana Scovassi
    Pages 307-323
  12. Sarah Conmy, Heinz-Peter Nasheuer
    Pages 325-336
  13. Back Matter
    Pages 337-340

About this book

Introduction

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.

This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Keywords

Chromosom DNA Viruses genes genetic disorders proteins regulation

Editors and affiliations

  • Heinz-Peter Nasheuer
    • 1
  1. 1.GalwayIreland

Bibliographic information

  • DOI https://doi.org/10.1007/978-90-481-3471-7
  • Copyright Information Springer Science+Business Media B.V. 2010
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-90-481-3470-0
  • Online ISBN 978-90-481-3471-7
  • Series Print ISSN 0306-0225
  • About this book