The DNA Damage Response: Implications on Cancer Formation and Treatment

  • Kum Kum Khanna
  • Yosef Shiloh

Table of contents

  1. Front Matter
    Pages i-xi
  2. Daniel Durocher
    Pages 1-24
  3. Daniel A. Mordes, David Cortez
    Pages 25-45
  4. Inbal Dar, Ari Barzilai
    Pages 65-79
  5. Ryo Sakasai, Randal S. Tibbetts
    Pages 81-107
  6. Julia Pagan, Emma Bolderson, Mathew Jones, Kum Kum Khanna
    Pages 109-131
  7. Tej K. Pandita
    Pages 133-156
  8. Laura M. Williamson, Chris T. Williamson, Susan P. Lees-Miller
    Pages 157-177
  9. Rabindra Roy, Sankar Mitra
    Pages 179-208
  10. Alan R. Lehmann
    Pages 209-234
  11. Mischa G. Vrouwe, Leon H.F. Mullenders
    Pages 235-259
  12. Keith W. Caldecott
    Pages 261-284
  13. Sachin Katyal, Peter J. McKinnon
    Pages 285-305
  14. Anne E. Kiltie, Marie Fernet, Janet Hall
    Pages 307-330
  15. Wen-Hsing Cheng, Byungchan Ahn, Vilhelm A. Bohr
    Pages 331-347
  16. Derek J. Richard, Kum Kum Khanna
    Pages 349-366
  17. Toshiyasu Taniguchi
    Pages 367-414
  18. Back Matter
    Pages 445-449

About this book


The book The DNA Damage Response: Implications on Cancer Formation and Treatment brings together a great collection of review articles. The articles have been written by a group of experts who have a deep knowledge of the recent advances in the fields of DNA damage signalling and repair and their implications in carcinogenesis.

The book is divided into chapters that deal with the elaborate surveillance system and repair mechanisms used by cells to suppress mutagenic lesions to avoid cancer. It provides snapshots of:
* current understanding of DNA damage signalling,
* cell cycle checkpoints,
* some of the major DNA repair pathways,
* functional links between DNA damage,
* genomic instability and cancer,
* implications of DNA damage for the development of new treatment modalities for cancer.


BRCA Chromosom DNA DNA Damage Telomere aging genes

Editors and affiliations

  • Kum Kum Khanna
    • 1
  • Yosef Shiloh
    • 2
  1. 1.Signal Transduction LaboratoryQueensland Institute of Medical ResearchHerstonAustralia
  2. 2.Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

Bibliographic information