Viral Proteases and Antiviral Protease Inhibitor Therapy

Proteases in Biology and Disease

  • Uwe Lendeckel
  • Nigel M. Hooper
Part of the Proteases in Biology and Disease book series (PBAD, volume 8)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Kuo-Chen Chou, Dong-Qing Wei, Qi-Shi Du, Suzanne Sirois, Hong-Bin Shen, Wei-Zhu Zhong
    Pages 1-23
  3. Irene T. Weber, Ying Zhang, Jozsef Tözsér
    Pages 25-45
  4. Philip Tedbury, Mark Harris
    Pages 47-69
  5. Marion Kaspari, Elke Bogner
    Pages 71-81
  6. Jeffrey-Tri Nguyen, Yoshiaki Kiso
    Pages 83-100
  7. David Neubauer, Jutta Steinberger, Tim Skern
    Pages 101-130
  8. Back Matter
    Pages 131-132

About this book

Introduction

The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

Keywords

AIDS antiviral drug biology infection infections viral infection virus

Editors and affiliations

  • Uwe Lendeckel
    • 1
  • Nigel M. Hooper
    • 2
  1. 1.Institute of Medical Biochemistry and Molecular BiologyErnst-Moritz-Arndt UniversityGreifswaldGermany
  2. 2.Institute of Molecular and Cellular Biology Faculty of Biological SciencesUniversity of LeedsLeedsUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-90-481-2348-3
  • Copyright Information Springer Netherlands 2009
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-90-481-2347-6
  • Online ISBN 978-90-481-2348-3
  • About this book