The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes

Molecular Genetic and Genomic Markers

  • Michael S. Ritsner

Table of contents

  1. Front Matter
    Pages i-xi
  2. Molecular Genetic and Genomic Markers

    1. Chantal Depondt
      Pages 65-75
    2. Gursharan Chana, Janet Kwok, Stephen J. Glatt, Ian P. Everall, Ming T. Tsuang
      Pages 77-93
    3. Michael S. Ritsner, Ehud Susser
      Pages 95-124
    4. Laura Mandelli, Alessandra Nivoli, Alessandro Serretti
      Pages 125-133
    5. Dalila Pinto, Dorothée Kasteleijn-Nolst Trenité, Dick Lindhout
      Pages 135-149
    6. Danielle M. Andrade
      Pages 151-159
    7. Katharina Domschke, Jürgen Deckert
      Pages 161-171
    8. Marco A. Grados, Rebecca Dang
      Pages 173-182
    9. Hiroki Ishiguro, Minori Koga, Yasue Horiuchi, Emmanuel S. Onaivi, Susumu Higuchi
      Pages 183-193
    10. R. H. Belmaker
      Pages 211-214
  3. Back Matter
    Pages 259-273

About this book


Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry.

The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.


Alzheimer gene expression genes genetics mood disorder neurology neuroscience phenotype psychiatric disorder psychiatry transcription

Editors and affiliations

  • Michael S. Ritsner
    • 1
    • 2
  1. 1.Israel Institute of TechnologyHaifa
  2. 2.Sha'ar Menashe Mental Health CenterHaderaIsrael

Bibliographic information