Imaging Tumor Response to Therapy

  • Aglietta Massimo 
  • Regge Daniele 

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Methodological Bases

    1. Front Matter
      Pages 1-1
    2. Giovannino Ciccone, Ileana Baldi
      Pages 3-14
    3. Francesco Sardanelli, Anastasia Esseridou, Angelo S. Del Sole, Luca M. Sconfienza
      Pages 15-37
  3. RECIST and Beyond: Assessing the Response to Treatment in Metastatic Disease

    1. Front Matter
      Pages 39-39
    2. Giovanni Grignani, Paola Boccone, Teresio Varetto, Stefano Cirillo
      Pages 41-60
    3. Cinzia Ortega, Camillo Porta, Manuela Racca, Filippo Russo
      Pages 61-75
    4. Lorenzo Capussotti, Luca Viganò, Francesco Leone, Delia Campanella
      Pages 77-91
  4. RECIST and Beyond: Assessing the Response to Treatment in Locally Advanced Disease

    1. Front Matter
      Pages 93-93
    2. Laura Martincich, Ilaria Bertotto, Filippo Montemurro
      Pages 95-108
    3. Massimo Bellomi, Tommaso De Pas, Adele Tessitore, Lorenzo Preda
      Pages 109-125
    4. Marcello Orsi, Claudio Losio, Michele Reni, Nadia Di Muzio, Francesco De Cobelli, Alessandro Del Maschio
      Pages 127-140
    5. Franco Brunello, Andrea Veltri
      Pages 141-157

About this book


Measurement of solid tumor response to treatment relies mainly on imaging. WHO tumor response criteria and, more recently, RECIST (response evaluation criteria in solid tumors) have provided means to objectively measure tumor response in clinical trials with imaging. These guidelines have been rapidly adopted in clinical practice to monitor patient treatment and for therapy planning. However, relying only on anatomical information is not always sufficient when evaluating new drugs that will reduce a tumor's functionality while preserving its size. Finding more reliable and reproducible measures of tumor response is one of the most important and difficult challenges facing modern radiology as it requires an entirely new approach to imaging.

The aim of this book is to address the assessment of response to treatment by adopting a multidisciplinary perspective, just as occurs in real life in a comprehensive cancer center. Oncologists and imaging experts consider two cancer models, locally advanced disease and metastatic disease, jointly exploring both conventional and advanced means of measuring response to standard treatment protocols and new targeted therapies.


Assessment of Response Functional Imaging Oncology Radiology

Editors and affiliations

  • Aglietta Massimo 
    • 1
  • Regge Daniele 
    • 2
  1. 1.Department of Medical OncologyUniversity of Turin Institute for Cancer Research and Treatment (IRCC)Candiolo (Turin)Italy
  2. 2.Radiology UnitInstitute for Cancer Research and Treatment (IRCC)Candiolo (Turin)Italy

Bibliographic information