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Advances in the Immunopathogenesis of Multiple Sclerosis

  • D. Gambi
  • P. A. Muraro
  • A. Lugaresi
  • U. Ecari
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XI
  2. P. A. Muraro, A. Lugaresi, D. Gambi
    Pages 1-2
  3. B. Mazzanti, E. Traggiai, B. Hemmer, R. Martin, L. Massacesi, M. Vergelli
    Pages 3-9
  4. B. Hemmer, C. Pinilla, B. Gran, H. F. McFarland, R. Houghten, R. Martin
    Pages 21-28
  5. G. Ristori, A. Perna, C. Montesperelli, L. Battistini, R. Bomprezzi, S. Cannoni et al.
    Pages 29-35
  6. R. Furlan, P. L. Poliani, A. Bergami, M. Gironi, G. Desina, G. Martino
    Pages 67-77
  7. A. Uccelli, G. L. Mancardi, D. Giunti, H. Brok, L. Roccatagliata, E. Capello et al.
    Pages 79-84
  8. Back Matter
    Pages 85-86

About these proceedings

Introduction

P.A. MURARO, A. LUGARESI, D. GAMBI Many of the pathological aspects of multiple sclerosis (MS) lesions have been known for over a century. It is only recently, however, that different patterns of demyelination have been linked to distinct pathways of immune-mediated tissue destruction. In particular, the inter-individual heterogeneity of MS lesions has suggested that different mechanisms may act in different patients, accounting for the variability observed in clinical course, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and response to immunomodulatory treatments. To provide an overview of the basic mechanisms possibly involved in MS lesion initiation and development, an international meeting was organized in the context of the annual Congress of the Italian Neuroimmunology Association (AINI), held at the University of Chieti, in Chieti Italy on 29 October 1998. The high standard of presentations prompted us to report them in extended form, to highlight recent pro­ gress in the understanding of basic mechanisms sustaining MS immuno­ pathogenesis. A central role in the possible mechanisms leading to myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. Studies on the myelin antigen-specific T cell repertoire have contributed significant advances to our knowledge of autoimmunity (Chapters 1,2).

Keywords

Antigen Nervous System T cell antigen presentation brain cognition cytokine innate immunity magnetic resonance magnetic resonance imaging magnetic resonance imaging (MRI) pathogenesis pathophysiology physiology

Editors and affiliations

  • D. Gambi
    • 1
  • P. A. Muraro
    • 1
    • 2
  • A. Lugaresi
    • 1
  • U. Ecari
  1. 1.Department of Oncology and Neuroscience, Medical SchoolUniversity G. D’AnnunzioChietiItaly
  2. 2.Neuroimmunology BranchNational Institute of Neurological Disorders and Stroke, NIHBethesdaUSA

Bibliographic information