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Laxatives

A Practical Guide

  • Francesco Capasso
  • Timothy S. Gaginella

Table of contents

  1. Front Matter
    Pages i-vii
  2. Francesco Capasso, Timothy S. Gaginella
    Pages 1-4
  3. Francesco Capasso, Timothy S. Gaginella
    Pages 5-10
  4. Francesco Capasso, Timothy S. Gaginella
    Pages 11-18
  5. Francesco Capasso, Timothy S. Gaginella
    Pages 19-21
  6. Francesco Capasso, Timothy S. Gaginella
    Pages 23-42
  7. Francesco Capasso, Timothy S. Gaginella
    Pages 43-45
  8. Francesco Capasso, Timothy S. Gaginella
    Pages 47-53
  9. Francesco Capasso, Timothy S. Gaginella
    Pages 55-61
  10. Francesco Capasso, Timothy S. Gaginella
    Pages 63-65
  11. Francesco Capasso, Timothy S. Gaginella
    Pages 67-67
  12. Francesco Capasso, Timothy S. Gaginella
    Pages 69-80
  13. Back Matter
    Pages 81-85

About this book

Introduction

Constipation is a common disorder that is often defined differently by patients and physicians. Clinically, constipation occurs when bowel move­ ments are difficult or painful. The "normality" of bowel movements, in terms of frequency, varies among individuals; frequency that is thought by one person to be constipation may be reported by another to be usual and thus normal. Often the perceived "need" to have a bowel movement leads to self-treatment with laxatives as these drugs are widely available without a prescription. This situation can raise problems in patient care, because of potential interactions between laxatives and other medications. Furthermore, chronic use (abuse) oflaxatives can cause serious medical consequences, causing patients to visit physicians, and even to be hospitalized for further evaluation and care. This has a financial impact on the patient, and on health care systems. It is essential that pharmacists, physicians and other health care practitioners counsel patients on the causes of constipation and the proper use oflaxatives. A medical work-up by a physician should be done to determine if the constipation is due to a pathological process. Often nor­ mal bowel function (for an invididual) can be maintained by diet and/or lifestyle. Most laxatives in use today are of botanical origin. Further research on the mechanism of action of these and synthetic laxatives is needed to bet­ ter define their pharmacology and toxicology.

Keywords

absorption castor oil constipation drugs laxatives pathophysiology pharmacology physiology secretion transport

Authors and affiliations

  • Francesco Capasso
    • 1
  • Timothy S. Gaginella
    • 2
  1. 1.Department of Experimental PharmacologyUniversity of Naples “Federico II”NaplesItaly
  2. 2.School of PharmacyUniversity of WisconsinMadisonUSA

Bibliographic information